825633-94-1

Basic information

• Product Name: 5-Iodo-2,3-dihydropyridazin-3-one
• Synonyms: 5-Iodo-2,3-dihydropyridazin-3-one;5-Iodopyridazin-3(2H)-one;5-Iodo-2H-pyridazin-3-one;3(2H)-Pyridazinone, 5-iodo-;5-Iodo-3(2H)-pyridazinone
• CAS NO: 825633-94-1
• Molecular Formula: C₄H₃IN₂O
• Molecular Weight: 221.981
• EINECS: 1533716-785-6
• Mol File: 825633-94-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 147-148 ºC
• Appearance: /
• Density: 2.40
• Refractive Index: 1.761
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.27±0.40(Predicted)
• CAS DataBase Reference: 5-Iodo-2,3-dihydropyridazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-2,3-dihydropyridazin-3-one(825633-94-1)
• EPA Substance Registry System: 5-Iodo-2,3-dihydropyridazin-3-one(825633-94-1)

Safety Data

• Hazardous Substances Data: 825633-94-1(Hazardous Substances Data)

Usage

General Description

5-Iodo-2,3-dihydropyridazin-3-one is a chemical compound that belongs to the class of organic compounds known as halopyridazines. These are aromatic compounds containing a halogen atom linked to a pyridazine ring. The molecular formula of 5-Iodo-2,3-dihydropyridazin-3-one is C4H3IN2O. As a relatively niche chemical compound, its specific attributes, purposes, or uses are not readily available or well-documented in common scientific literature or databases. The various biological, environmental, or synthetic roles and implications of the compound remain largely understudied and unspecified. It may be potentially used or studied in the realm of organic chemistry or related scientific fields.

InChI:InChI=1/C4H3IN2O/c5-3-1-4(8)7-6-2-3/h1-2H,(H,7,8)

Upstream product

• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 825633-93-0 2-benzyl-5-iodo-2,3-dihydropyridazin-3-one 

Downstream Products

• 847026-42-0 5-iodo-2-phenyl-2,3-dihydropyridazin-3-one 
• 825633-93-0 2-benzyl-5-iodo-2,3-dihydropyridazin-3-one 
• 1453852-63-5 (S)-2-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-5-iodopyridazin-3(2H)-one 
• 1243253-45-3 5-(4-chlorobenzylthio)pyridazin-3(2H)-one 
• 697739-27-8 4-[4-(trifluoromethyl)phenyl]-1H-pyridazin-6-one 
• 153239-91-9 5-iodo-2-methylpyridazin-3(2H)-one 

Relevant articles and documents

Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists

A novel series of 4-pyridazin-3-one and 5-pyridazin-3-one analogues were designed and synthesized as H3R antagonists. Structure-activity relationship revealed the 5-pyridazin-3-ones 8a and S-methyl 8b had excellent human and rat H3R affinities, and acceptable pharmacokinetic properties. In vivo evaluation of 8a showed potent activity in the rat dipsogenia model and robust wake-promoting activity in the rat EEG/EMG model.

SUBSTITUTED PYRIDAZINONE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS

The present invention provides compounds according to Formulas I, II, III, IV, V, VI, VII or VIII; their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.