825649-03-4

Basic information

• Product Name: 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-phenylselenylmethyl-2'-deoxyuridine
• Synonyms: 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-phenylselenylmethyl-2'-deoxyuridine
• CAS NO: 825649-03-4
• Molecular Weight: 874.098
• Mol File: 825649-03-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-phenylselenylmethyl-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-phenylselenylmethyl-2'-deoxyuridine(825649-03-4)
• EPA Substance Registry System: 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-phenylselenylmethyl-2'-deoxyuridine(825649-03-4)

Safety Data

• Hazardous Substances Data: 825649-03-4(Hazardous Substances Data)

Upstream product

• 118068-35-2 3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine 
• 1666-13-3 diphenyl diselenide 
• 118070-22-7 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-bromomethyl-2'-deoxyuridine 

Downstream Products

• 5116-24-5 2'-deoxy-5-(hydroxymethyl)uridine 
• 825649-02-3 5-(N-methoxymethylamine)-2'-deoxyuridine 

Relevant articles and documents

Mild generation of 5-(2′-deoxyuridinyl)methyl radical from a phenyl selenide precursor

(Chemical Equation Presented) 5-(2′-Deoxyuridinyl)methyl radical (1) resulting from formal hydrogen atom abstraction from the methyl group of thymidine is produced from the respective phenyl selenide precursor (2) via 350 nm photolysis or mild thermolysis (37°C in the presence of glutathione) under aerobic or anaerobic conditions. The mild thermal generation of a nucleoside radical provides an alternative to previously reported photochemical methods, which are not always compatible with nucleic acids.