82625-46-5

Basic information

• Product Name: Benzaldehyde, 4-[3-(1-piperidinyl)propoxy]-
• CAS NO: 82625-46-5
• Molecular Formula: C15H21NO2
• Molecular Weight: 247.337
• Mol File: 82625-46-5.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-[3-(1-piperidinyl)propoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-[3-(1-piperidinyl)propoxy]-(82625-46-5)
• EPA Substance Registry System: Benzaldehyde, 4-[3-(1-piperidinyl)propoxy]-(82625-46-5)

Safety Data

• Hazardous Substances Data: 82625-46-5(Hazardous Substances Data)

Upstream product

• 1458-63-5 N-(3-chloropropyl)-piperidine 
• 123-08-0 4-hydroxy-benzaldehyde 
• 110-89-4 piperidine 
• 82625-25-0 4-(3-chloropropoxy)benzaldehyde 
• 104-58-5 3-piperidinopropan-1-ol 
• 202191-53-5 toluene-4-sulfonic acid 3-(4-formyl-phenoxy)-propyl ester 
• 109-70-6 1.3-chlorobromopropane 
• 17954-81-3 4-(3-bromopropoxy)benzaldehyde 
• 93543-57-8 3-piperidin-1-yl-propylamine hydrochloride 
• 5472-49-1 1-(3-chloropropyl)piperidine hydrochloride 

Downstream Products

• 1028458-62-9 (1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)methanol 
• 1609110-32-8 1-(4-(3-(piperidin-1-yl)propoxy)benzyl)-N-(prop-2-ynyl)piperidine-4-carboxamide 
• 1609110-33-9 N-ethyl-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine-4-carboxamide 
• 464898-19-9 (4-(3-(piperidin-1-yl)propoxy)phenyl)methanol 
• 1609110-28-2 1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-carbohydrazide 
• 1609110-29-3 2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate 
• 1609110-27-1 ethyl 1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine-4-carboxylate 

Relevant articles and documents

Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation

Alzheime?s disease (AD) is the most prominent neurodegenerative disorder with high medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where β-amyloid structures (Aβ) build toxic oligomers. Design of disease modifying multi target directed ligand (MTDL) has been performed, which disable PPI on the one hand and on the other hand, act as procognitive antagonists at the histamine H3 receptor (H3R). The synthetized compounds are structurally based on peptidomimetic amino acid-like structures mainly as keto, diketo-, or acyl variations of a piperazine moiety connected to an H3R pharmacophore. Most of them showed low nanomolar affinities at H3R and some with promising affinity to Aβ-monomers. The structure–activity relationships (SAR) described offer new possibilities for MTDL with an optimized profile combining symptomatic and potential causal therapeutic approaches in AD.

Design, synthesis and biological evaluation of 2-styryl-5-hydroxy-4-pyrone derivatives and analogues as multiple functional agents with the potential for the treatment of Alzheimer's disease

A novel series of 2-styryl-5-hydroxy-4-pyrone derivatives and analogues were designed and synthesized as H3 receptor antagonism based multitarget-directed ligands (MTDLs) for AD therapy using pharmacophore-combine strategy. The 2-styryl-5-hydro

Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease

A series of novel chalcone-O-alkylamine derivatives were designed, synthesized and evaluated as multifunctional anti-Alzheimer's disease agents. Based on the experimental results, compound 23c exhibited good inhibitory potency on both acetylcholinesterase