82689-15-4

Basic information

• Product Name: BOC-TYR(BZL)-ALDEHYDE
• Synonyms: O-Benzyl-N-Boc-L-tyrosinal;O-benzyl-N-(tert-butoxycarbonyl)-L-tyrosinal;tert-Butyl (S)-(1-(4-(benzyloxy)phenyl)-3-oxopropan-2-yl)carbamate;tert-butyl N-[(1S)-1-[(4-benzyloxyphenyl)methyl]-2-oxo-ethyl]carbamate;Carbamic acid, N-[(1S)-1-formyl-2-[4-(phenylmethoxy)phenyl]ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 82689-15-4
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.431
• Mol File: 82689-15-4.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 501.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.124±0.06 g/cm3(Predicted)
• Storage Temp.: Store at 0°C
• PKA: 11.23±0.46(Predicted)
• CAS DataBase Reference: BOC-TYR(BZL)-ALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-TYR(BZL)-ALDEHYDE(82689-15-4)
• EPA Substance Registry System: BOC-TYR(BZL)-ALDEHYDE(82689-15-4)

Safety Data

• Hazardous Substances Data: 82689-15-4(Hazardous Substances Data)

Upstream product

• 27513-44-6 N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester 
• 126410-45-5 tert-butyl (S)-{3-[4-(benzyloxy)phenyl]-1-[methoxy(methyl)amino]-1-oxo-propan-2-yl}carbamate 
• 153815-62-4 Boc-Tyr(OBz)-NCA 
• 100-39-0 benzyl bromide 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 79-37-8 oxalyl dichloride 
• 66605-58-1 O-benzyl N-Boc-L-tyrosinol 
• 7646-93-7 potassium hydrogensulfate 
• 60-29-7 diethyl ether 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 1026977-99-0 C₂₆H₃₃NO₇ 

Downstream Products

• 927425-95-4 [2-(4-benzyloxy-phenyl)-1-(1H-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 927425-99-8 [2-(4-benzyloxy-phenyl)-1-oxazol-5-yl-ethyl]-carbamic acid tert-butyl ester 
• 927426-05-9 C₂₂H₂₈N₂O₄ 
• 1004287-05-1 tert-butyl (S)-1-(benzylamino)-3-(4-(benzyloxy)phenyl)propan-2-ylcarbamate 
• 1008777-00-1 (3R,4S)-5-[4-(benzyloxy)phenyl]-4-(tert-butoxycarbonylamino)-3-hydroxypentanoic acid ethyl ester 
• 1008776-84-8 (3S,4S)-5-[4-(benzyloxy)phenyl]-4-(tert-butoxycarbonylamino)-3-hydroxypentanoic acid ethyl ester 
• 1200041-07-1 ethyl (S)-5-(4-(benzyloxy)phenyl)-4-(tert-butoxycarbonylamino)-2-en-2-methylpentanoate 
• 927425-96-5 C₁₈H₁₉N₃O 
• 927426-00-4 C₁₈H₁₈N₂O₂ 

Relevant articles and documents

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.

CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.