82780-48-1

Basic information

• Product Name: Benzamide, 2-methoxy-N,N,6-trimethyl-
• CAS NO: 82780-48-1
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Mol File: 82780-48-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-methoxy-N,N,6-trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-methoxy-N,N,6-trimethyl-(82780-48-1)
• EPA Substance Registry System: Benzamide, 2-methoxy-N,N,6-trimethyl-(82780-48-1)

Safety Data

• Hazardous Substances Data: 82780-48-1(Hazardous Substances Data)

Upstream product

• 7291-34-1 2-methoxy-N,N-dimethylbenzamide 
• 74-88-4 methyl iodide 
• 3400-35-9 2-methoxy-N-methylbenzamide 

Downstream Products

• 90661-56-6 2-[2-Hydroxy-3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-6-methoxy-N,N-dimethyl-benzamide 
• 82780-49-2 2-[2-Hydroxy-2-(4-methoxy-phenyl)-ethyl]-6-methoxy-N,N-dimethyl-benzamide 
• 82780-50-5 1-(3-benzyloxy-4-methoxyphenyl)-2-(2-N,N-dimethylamido-3-methoxyphenyl)ethanol 
• 146518-57-2 1-(3-benzyloxy-4-methoxyphenyl)-2-(2-N,N-dimethylamido-3-methoxyphenyl)ethanone 
• 480-47-7 hydrangenol 
• 52213-49-7 (+/-)-3-(4-methoxyphenyl)-8-hydroxy-3,4-dihydroisocoumarin 
• 82780-51-6 (+/-)-3-(4-methoxyphenyl)-8-methoxy-3,4-dihydroisocoumarin 
• 82780-52-7 (+/-)-phyllodulcin 3'-benzyl-8-methyl ether 
• 55555-33-4 phyllodulcin 
• 90661-57-7 2-Methoxy-N,N-dimethyl-6-[3-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-propyl]-benzamide 
• 90661-58-8 2-((Z)-4-Hydroxy-2-oxo-pent-3-enyl)-6-methoxy-N,N-dimethyl-benzamide 

Relevant articles and documents

Ortho-Lithiated Tertiary Benzamides. Chain Extension via o-Toluamide Anion and General Synthesis of Isocoumarins Including Hydrangenol and Phyllodulcin

Lithiation of N,N-diethyl-2-methylbenzamide (2a) followed by condensation with aromatic aldehydes and basic hydrolysis leads to 3-aryl-3,4-dihydroisocoumarins 4 in modest overall yields.Adoption of this methodology to N,N-dimethyl-2-methyl-6-methoxybenzamide (7b) provides isocoumarins 9a and 9b which by selective demethylation procedures yields hydrangenol (10a) and phyllodulcin (10c), naturally occurring isocoumarins of pharmacological interest.A one-pot, abbreviated procedure for the preparation of both 9a and 9b starting with N,N-Dimethyl-2-methoxybenzamide (6c) is also described.