828247-90-1

Basic information

• Product Name: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-cyanoethoxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• CAS NO: 828247-90-1
• Molecular Formula: C44H54N5O10P
• Molecular Weight: 843.914
• Mol File: 828247-90-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-cyanoethoxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite](CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-cyanoethoxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite](828247-90-1)
• EPA Substance Registry System: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-cyanoethoxy)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite](828247-90-1)

Safety Data

• Hazardous Substances Data: 828247-90-1(Hazardous Substances Data)

Upstream product

• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 828247-82-1 3-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yloxy]-ethoxy}-propionitrile 
• 213548-64-2 2'-O-[1-(2-cyanoethoxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 3386-87-6 1,2-bis-(2-cyanoethoxy)ethane 

Downstream Products

• 2415-43-2 uridylyl-3',5'-uridine 
• 847979-67-3 C₆₃H₆₃N₆O₂₁P 

Relevant articles and documents

Oligoribonucleotide synthesis by the use of 1-(2-cyanoethoxy)ethyl (CEE) as a 2′-hydroxy protecting group

A novel method for the synthesis of oligoribonucleotide using 1-(2-cyanoethoxy)ethyl (CEE) as a 2′-hydroxy protecting group has been developed. A novel method for the synthesis of oligoribonucleotides using 1-(2-cyanoethoxy)ethyl (CEE) as a 2′-hydroxy protecting group has been developed. A CEE group was introduced to the 2′-position of N-acyl-3′,5′-O-silyl-protected ribonucleosides under acidic conditions in good yields. The 2′-O-CEE group was found to be stable in an aqueous or ethanolic ammonia and was quickly removed by treatment with anhydrous tetrabutylammonium fluoride (TBAF). A combination of the use of N-acyl and 2′-O-CEE protecting groups enabled a reliable and complete two-step deprotection, first with NH3-EtOH, then with TBAF in THF, without cleavage of internucleotidic linkages.