82827-16-5

Basic information

• Product Name: 2-amino-5-bromo-N-phenylbenzamide
• Synonyms: 2-amino-5-bromo-N-phenylbenzamide
• CAS NO: 82827-16-5
• Molecular Weight: 291.147
• Mol File: 82827-16-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-amino-5-bromo-N-phenylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-bromo-N-phenylbenzamide(82827-16-5)
• EPA Substance Registry System: 2-amino-5-bromo-N-phenylbenzamide(82827-16-5)

Safety Data

• Hazardous Substances Data: 82827-16-5(Hazardous Substances Data)

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 62-53-3 aniline 
• 1108665-60-6 2-amino-5-bromobenzoic acid chloride 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 4692-98-2 5-bromoisatoic anhydride 

Downstream Products

• 92103-93-0 6-bromo-3-phenyl-4(3H)-quinazolinone 
• 4546-25-2 6-bromo-2-methyl-3-phenylquinazolin-4(3H)-one 

Relevant articles and documents

Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions

Alcohols and ethers were identified as sustainable methine sources for synthesizing quinazolinone and benzimidazole derivatives using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone (2e′), 2f′ (a common precursor of rutaecarpine and (±) evodiamine), and dimedazole (6d). Notable features of this method include its low toxicity, use of commercial feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.

NaNO2/I2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization.

SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)