82846-48-8 Usage
Description
(8E,12Z)-10-hydroxyoctadeca-8,12-dienoic acid, also known as 10-HODE, is a fatty acid derived from linoleic acid, an omega-6 polyunsaturated fatty acid. It is formed through the oxidation of linoleic acid by lipoxygenase enzymes. 10-HODE has been found to possess anti-inflammatory properties and plays a role in various physiological processes, including lipid metabolism, immune response, and cell signaling. It has also been implicated in the pathology of certain diseases, such as atherosclerosis, cancer, and neurodegenerative disorders. 10-HODE can be found in various tissues and is often measured as a biomarker for oxidative stress and inflammation in the body. Additionally, it has potential as a therapeutic target for the development of drugs to treat inflammatory and metabolic disorders.
Uses
Used in Pharmaceutical Applications:
10-HODE is used as a therapeutic target for the development of drugs to treat inflammatory and metabolic disorders due to its anti-inflammatory properties and involvement in physiological processes.
Used in Diagnostic Applications:
10-HODE is used as a biomarker for oxidative stress and inflammation in the body, helping in the detection and monitoring of various diseases.
Used in Research Applications:
10-HODE is used in research to study its role in lipid metabolism, immune response, and cell signaling, as well as its implications in the pathology of diseases like atherosclerosis, cancer, and neurodegenerative disorders.
Used in Antioxidant Applications:
10-HODE may be used as an antioxidant in the development of products aimed at reducing oxidative stress in the body.
Used in Nutritional Applications:
10-HODE could potentially be incorporated into nutritional supplements or functional foods for its anti-inflammatory and health-promoting properties.
Used in Cosmetic Applications:
10-HODE might be used in the cosmetic industry for products targeting inflammation and oxidative stress, potentially benefiting skin health and appearance.
Used in the Food Industry:
10-HODE could be used in the development of functional foods or additives that promote health by reducing inflammation and oxidative stress.
Check Digit Verification of cas no
The CAS Registry Mumber 82846-48-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,8,4 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 82846-48:
(7*8)+(6*2)+(5*8)+(4*4)+(3*6)+(2*4)+(1*8)=158
158 % 10 = 8
So 82846-48-8 is a valid CAS Registry Number.
82846-48-8Relevant articles and documents
Preparation of fatty acid cholesterol ester hydroperoxides by photosensitized oxidation
El Hafidi,Michel,Bascoul,Crastes De Paulet
, p. 127 - 138 (2007/10/03)
Preparation of fatty acid cholesterol ester hydroperoxides was undertaken with the purpose of evaluating their biological effects on cell growth. Cholesterol stearate, oleate, linoleate and α-linolenate were oxidized using methylene blue as a photosensitizer. The structures of all compounds were established by mass spectrometry and by nuclear magnetic resonance. The photosensitized oxidation of cholesterol oleate gave two hydroperoxide isomers: 9-hydroperoxy-trans-10-octadecenoate, and 10-hydroperoxy-trans-8-octadecenoate. In the case of the cholesterol linoleate, hydroperoxide isomers formed were: 9-hydroperoxy-trans-10, cis-12-octadecadienoate; 10-hydroperoxy-trans-8, cis-12-octadecadienoate; 12-hydroperoxy-cis-9, trans-13-octadecadienoate; 13-hydroperoxy-cis-9, trans-11-octadecadienoate. The oxidation of the cholesterol α-linolenate gave a mixture of six hydroperoxide isomers, at positions 9, 10, 12, 13, 15 and 16 of the fatty acid chain. The photosensitized oxidation of cholesterol stearate produced a formation of hydroperoxide at position 5α of cholesterol. The same hydroperoxide isomers on the fatty acid chain were obtained as described in the literature for the fatty acid methyl esters. Copyright (C) 1999 Elsevier Science Ireland Ltd.
10-Hydroperoxy-8,12-octadecadienoic Acid: A Diagnostic Probe of Alkoxy Radical Generation in Metal-Hydroperoxide Reactions
Labeque, Regine,Marnett, Lawrence J.
, p. 2828 - 2829 (2007/10/02)
-
