82894-83-5Relevant articles and documents
Spin-labeling luotonin A compound as well as preparation method and application thereof
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Paragraph 0008; 0017; 0018, (2017/08/27)
The invention discloses a spin-labeling luotonin A compound of formula (I) as shown in the specification, as well as a preparation method and application of the compound. In-vitro antitumor activity screening results show that compared with luotonin A, the spin-labeling luotonin A compound disclosed by the invention is relatively intense in inhibition activity on human lung adenocarcinoma cells (A549), human breast cancer cell lines (MDA-MB-468), human ovarian neoplasm cells (SKOV3) and human colon cancer cell lines (HCT 116), and has good application prospects.
Approaches to the synthesis of a water-soluble carboxy nitroxide
Thomas, Komba,Chalmers, Benjamin A.,Fairfull-Smith, Kathryn E.,Bottle, Steven E.
, p. 853 - 857 (2013/03/29)
The robust and diversely useful isoindoline nitroxide, 5-carboxy-1,1,3,3- tetramethylisoindolin-2-yloxyl (1; CTMIO), has previously been synthesised in low-to-moderate yields from phthalic anhydride (3). Recent interest in its biological potential as a potent antioxidant and in other areas has seen an increased demand for its production. Herein, three new synthetic routes to CTMIO are presented and their efficiencies assessed. Two routes, via the nitrile 9 and the formyl compound 11, derive from 5-bromo-1,1,3,3-tetramethylisoindoline (6). The third approach starts from the readily accessible starting material, 4-methylphthalic anhydride (12), and proceeds by a methylarene oxidation with potassium permanganate. The three new approaches yield CTMIO in comparable overall yields (16-18 %); however, the synthetic efficiency is most improved when employing the nitrile intermediate 9. Copyright
Conformationally unambiguous spin labeling for distance measurements
Sajid, Muhammad,Jeschke, Gunnar,Wiebcke, Michael,Godt, Adelheid
supporting information; experimental part, p. 12960 - 12962 (2010/07/03)
An iDEER about molecular structure: Measurements of interspin distances through double electron-electron resonance (DEER) experiments allow information to be gained about the structure of molecules (see figure). The less variability in the orientation of the N-O axis of nitroxyl spin labels with respect to the labeled molecule, the smaller the distribution of the interspin distance and thus the better the conclusion.