82921-54-8

Basic information

• Product Name: N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide
• Synonyms: N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide
• CAS NO: 82921-54-8
• Molecular Weight: 518.55
• Mol File: 82921-54-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide(82921-54-8)
• EPA Substance Registry System: N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide(82921-54-8)

Safety Data

• Hazardous Substances Data: 82921-54-8(Hazardous Substances Data)

Upstream product

• 1849-36-1 para-nitrobenzenethiol 
• 449753-14-4 2'-deoxy-5'-O-(dimethoxytrityl)-2-N-(2-methylpropanoyl)-6-O-{2-[(4-nitrophenyl)sulfanyl]ethyl}guanosine 
• 68892-42-2 N-isobutyryl-2'-deoxyguanosine 
• 13287-76-8 2-(p-nitrophenylthio)ethanol 
• 82921-43-5 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine 

Downstream Products

• 118088-99-6 N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide 
• 118088-95-2 N-{9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-benzenesulfinyl)-ethoxy]-9H-purin-2-yl}-isobutyramide 
• 449753-14-4 2'-deoxy-5'-O-(dimethoxytrityl)-2-N-(2-methylpropanoyl)-6-O-{2-[(4-nitrophenyl)sulfanyl]ethyl}guanosine 

Relevant articles and documents

Synthesis and binding properties of oligodeoxynucleotides containing phenylphosphon(othio)ate linkages

A method for the synthesis of chimeric oligodeoxynucleotides comprised of phosphodiester and phenylphosphonate [3'O-P(=O)(C6H5)-O-5'] or phenylphosphono-thioate [3'-O-P(=S)(C6H5)-O-5'] linkages has been develope

A NEW STRATEGY FOR THE PROTECTION OF DEOXYGUANOSINE DURING OLIGONUCLEOTIDE SYNTHESIS

The protection of the 6-oxo group of deoxyguanosine with the 2-trimethylsilylethyl (2), phenylthioethyl (3), 4-nitrophenylthioethyl (4), 4-nitrophenethyl (5), and cyanoethyl (6) groups is described.Each protecting group is introduced in good yield and is cleaved under mild conditions.Compatibility with the various approaches to oligonucleotide synthesis is discussed.