83089-02-5

Basic information

• Product Name: 2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetic acid
• Synonyms: 2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetic acid
• CAS NO: 83089-02-5
• Molecular Weight: 304.348
• Mol File: 83089-02-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetic acid(83089-02-5)
• EPA Substance Registry System: 2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetic acid(83089-02-5)

Safety Data

• Hazardous Substances Data: 83089-02-5(Hazardous Substances Data)

Upstream product

• 3261-87-8 1,4-oxathiane-2,6-dione 
• 63-74-1 sulfanilamide 

Downstream Products

• 1393724-77-0 (R)-methyl 3-(4-hydroxyphenyl)-2-(2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetamido)propanoate 
• 1393724-76-9 (S)-methyl 3-(4-hydroxyphenyl)-2-(2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetamido)propanoate 
• 1393724-80-5 (R)-3-(4-isobutoxyphenyl)-2-(2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetamido)propanoic acid 
• 1393724-79-2 (S)-3-(4-isobutoxyphenyl)-2-(2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetamido)propanoic acid 
• 1393724-78-1 (S)-3-(4-ethoxyphenyl)-2-(2-(2-oxo-2-(4-sulfamoylphenylamino)ethylthio)acetamido)propanoic acid 

Relevant articles and documents

Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library

Libraries of chemical compounds individually coupled to encoding DNA tags (DNA-encoded chemical libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNAencoded chemical library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments. High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic analysis of selection strategies and statistically robust identification of binding molecules. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by molecular docking. Our findings suggest that DNA-encoded chemical libraries allow the facile identification of drug-like ligands principally to any protein of choice, including molecules capable of disrupting high-affinity protein-protein interactions.