83199-47-7 Usage
Description
CHOLESTEROL-25,26,26,26,27,27,27-D7, also known as Cholesterol-d7, is a stable isotope-labeled form of cholesterol intended for use as an internal standard in the quantification of cholesterol by gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS). Cholesterol is a major sterol produced in mammalian cells that is essential for cell viability and proliferation. It is a component of mammalian cell membranes and plays a crucial role in the synthesis of steroid hormones, bile acids, and the active form of vitamin D. Impaired cholesterol homeostasis is associated with the development of various diseases, including fatty liver, diabetes, gallstones, dyslipidemia, atherosclerosis, heart attack, and stroke.
Uses
Used in Analytical Chemistry:
CHOLESTEROL-25,26,26,26,27,27,27-D7 is used as an internal standard for the accurate quantification of cholesterol levels in biological samples. It helps to improve the precision and accuracy of cholesterol measurements by compensating for matrix effects, ionization suppression, or enhancement during the analysis process.
Used in Pharmaceutical Industry:
CHOLESTEROL-25,26,26,26,27,27,27-D7 is used as a reference material in the development and validation of analytical methods for cholesterol quantification in pharmaceutical formulations. It ensures the reliability and reproducibility of the methods, which is crucial for the quality control of cholesterol-containing drugs.
Used in Research and Development:
CHOLESTEROL-25,26,26,26,27,27,27-D7 is used as a practical tracer for studies of cholesterol metabolism in humans. It helps researchers to investigate the mechanisms of cholesterol synthesis, transport, and regulation, as well as the role of cholesterol in various physiological and pathological processes.
Used in Clinical Diagnostics:
CHOLESTEROL-25,26,26,26,27,27,27-D7 can be used as a reference material in clinical diagnostics to ensure the accuracy and reliability of cholesterol measurements in patient samples. This is important for the diagnosis and monitoring of various cholesterol-related diseases, such as atherosclerosis, heart attack, and stroke.
Used in Nutritional Studies:
CHOLESTEROL-25,26,26,26,27,27,27-D7 can be used in nutritional studies to investigate the effects of diet and lifestyle on cholesterol levels and metabolism. This can help to develop evidence-based guidelines for the prevention and management of cholesterol-related diseases.
Used in Toxicology Studies:
CHOLESTEROL-25,26,26,26,27,27,27-D7 can be used in toxicology studies to assess the potential effects of chemicals, drugs, or environmental factors on cholesterol homeostasis. This can provide valuable information for the evaluation of the safety and risk associated with exposure to these substances.
Check Digit Verification of cas no
The CAS Registry Mumber 83199-47-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,1,9 and 9 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 83199-47:
(7*8)+(6*3)+(5*1)+(4*9)+(3*9)+(2*4)+(1*7)=157
157 % 10 = 7
So 83199-47-7 is a valid CAS Registry Number.
InChI:InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3,18D
83199-47-7Relevant articles and documents
Synthesis of [25, 26, 26, 26, 27, 27, 27-d7]-cholesterol
Chu, Guo-Hua,Li, Pui-Kai
, p. 773 - 779 (2000)
An efficient synthesis of [25, 26, 26, 26, 27, 27,27-d7]-cholesterol 1, a useful tool for the measurement of cholesterol absorption, is described. Commercially available stigmasterol is converted into the known aldehyde 2 which was then transformed to the d7-cholesterol 1 through a reaction sequence of 8 steps in an overall yield of 22.5%. Copyright
