832-92-8

Basic information

• Product Name: MESCALINE HYDROCHLORIDE
• Synonyms: MESCALINE HYDROCHLORIDE;3,4,5-trimethoxy-beta-phenylethylaminehydrochloride;3,4,5-trimethoxyphenethylaminehydrochloride;3,4,5-trimethoxy-phenethylaminhydrochloride;mescaline hcl methanol solution;mescaline hcl--dea schedule I item;Mescalin, Mescaline, Mezcaline, NSC 30419, TMPEA, 3,4,5-Trimethoxybenzeneethanamine, Hydrochloride;2-(3,4,5-TRIMETHOXYPHENYL)ETHYLAMINEHYDROCHLORIDE
• CAS NO: 832-92-8
• Molecular Formula: C₁₁H₁₇NO₃*ClH
• Molecular Weight: 247.72
• EINECS: 212-626-3
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 832-92-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 180-182°C
• Boiling Point: 312.1 °C at 760 mmHg
• Flash Point: 9℃
• Appearance: /
• Vapor Pressure: 0.000541mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: MESCALINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: MESCALINE HYDROCHLORIDE(832-92-8)
• EPA Substance Registry System: MESCALINE HYDROCHLORIDE(832-92-8)

Safety Data

• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-36/38-23/24/25-11
• Safety Statements: 22-26-36-45-36/37-24-16-7
• RIDADR: UN 1230 3/PG 2
• WGK Germany: 3
• RTECS: SI2800000
• Hazardous Substances Data: 832-92-8(Hazardous Substances Data)

Usage

Description

Mescaline Hydrochloride is a synthetic form of the naturally occurring psychedelic phenethylamine, mescaline, which is predominantly found in cacti such as peyote (Lophophora williamsii). It is an off-white solid that binds and activates serotonin receptors, with a preference for 5-HT2A over 5-HT2C. Mescaline Hydrochloride is intended for research and forensic purposes and is classified as a controlled substance due to its hallucinogenic effects.

Uses

Used in Research Applications:
Mescaline Hydrochloride is used as a research chemical for studying the effects of psychedelic substances on the human brain and their potential therapeutic applications. It helps researchers understand the mechanisms of action and the role of serotonin receptors in modulating mood, perception, and cognition.
Used in Forensic Analysis:
Mescaline Hydrochloride is utilized in forensic analysis to identify and analyze the presence of this controlled substance in biological samples, such as blood, urine, or tissue. This is crucial for legal and investigative purposes, as well as for understanding the prevalence and impact of hallucinogenic substances in society.
Used in Controlled Substance Regulation:
As a controlled substance, Mescaline Hydrochloride is subject to strict regulations and monitoring by government agencies. Its use is limited to research and forensic purposes, ensuring that it is not misused or abused for recreational or illegal activities.

InChI:InChI=1/C11H17NO3.ClH/c1-13-9-6-8(4-5-12)7-10(14-2)11(9)15-3;/h6-7H,4-5,12H2,1-3H3;1H

Upstream product

• 6316-70-7 3,4,5-trimethoxy-β-nitrostyrene 
• 1436392-06-1 benzyl 3,4,5-trimethoxyphenethylcarbamate 
• 25173-72-2 3-(3,4,5-trimethoxyphenyl)propanoic acid 

Downstream Products

• 1204357-69-6 1-(2,6-dichlorophenyl)-6,7,8-trimethoxy-3,4-dihydroisoquinoline 
• 1383540-87-1 1-(3,5-dinitrophenyl)-6,7,8-trimethoxy-3,4-dihydroisoquinoline hydrochloride 
• 1383540-88-2 6,7,8-trimethoxy-1-(4-nitrophenyl)-3,4-dihydroisoquinoline hydrochloride 
• 1204357-73-2 2-methoxy-5-(6,7,8-trimethoxy-3,4-dihydroisoquinolin-1-yl)phenol 
• 1383540-90-6 2-methoxy-5-(6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)phenol 
• 1383540-91-7 6,7,8-trimethoxy-1-(4-methoxy-3-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1204357-83-4 1-(4-fluorophenyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1204357-81-2 1-(4-fluorophenyl)-6,7,8-trimethoxyisoquinoline 
• 1383540-81-5 6,7,8-trimethoxy-1-phenyl-3,4-dihydroisoquinoline hydrochloride 
• 1383540-82-6 6,7,8-trimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline hydrochloride 
• 1204357-74-3 1-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-3,4-dihydroisoquinoline 
• 1204357-78-7 6,7,8-trimethoxy-1-(4-methoxy-3-nitrophenyl)-3,4-dihydroisoquinoline 
• 1383540-83-7 6,7,8-trimethoxy-1-p-tolyl-3,4-dihydroisoquinoline hydrochloride 
• 1383540-84-8 6,7,8-trimethoxy-1-m-tolyl-3,4-dihydroisoquinoline hydrochloride 

Relevant articles and documents

Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine

A series of novel sulfamides incorporating the dopamine scaffold were synthesized. Reaction of amines and tert-butyl-alcohol/benzyl alcohol in the presence of chlorosulfonyl isocyanate (CSI) afforded sulfamoyl carbamates, which were converted to the title compounds by treatment with trifluoroacetic acid or by palladium-catalyzed hydrogenolysis. Inhibition of six α-carbonic anhydrases (CAs, EC 4.2.1.1), that is, CA I, CA II, CA VA, CA IX, CA XII and CA XIV, and two β-CAs from Candida glabrata (CgCA) and Mycobacterium tuberculosis (Rv3588) with these sulfamides was investigated. All CA isozymes were inhibited in the low micromolar to nanomolar range by the dopamine sulfamide analogues. Kis were in the range of 0.061-1.822 μM for CA I, 1.47-2.94 nM for CA II, 2.25-3.34 μM for CA VA, 0.041-0.37 μM for CA IX, 0.021-1.52 μM for CA XII, 0.007-0.219 μM for CA XIV, 0.35-5.31 μM for CgCA and 0.465-4.29 μM for Rv3588. The synthesized sulfamides may lead to inhibitors targeting medicinally relevant CA isoforms with potential applications as antiepileptic, antiobesity antitumor agents or anti-infective.