83249-04-1

Basic information

• Product Name: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid
• Synonyms: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid
• CAS NO: 83249-04-1
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.22248
• Mol File: 83249-04-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid(83249-04-1)
• EPA Substance Registry System: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid(83249-04-1)

Safety Data

• Hazardous Substances Data: 83249-04-1(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 65862-03-5 methyl 3-phenyl-2,2-dichlorobicyclo<1.1.1>pentane-1-carboxylic acid 
• 30493-96-0 methyl 3-phenylbicyclo<1.1.0>butane-1-carboxylate 
• 36126-39-3 methyl 3-bromo-3-phenylcyclobutane-1-carboxylate 
• 227935-29-7 methyl 3-phenylcyclobutane-1-carboxylate 
• 83249-09-6 methyl 3-phenylbicyclo<1.1.1>pentane-1-carboxylate 
• 124-38-9 carbon dioxide 
• 35634-10-7 [1.1.1]propellane 
• 100-58-3 phenylmagnesium bromide 
• 30493-96-0 methyl 3-phenylbicyclo<1.1.0>butanecarboxylate 
• 30493-91-5 methyl 3-chloro-3-phenylcyclobutane-1-carboxylate 
• 23761-27-5 3-phenyl-3-chlorocyclobutane-1-carboxylic acid 
• 23761-26-4 3-phenyl-3-hydroxycyclobutane-1-carboxylic acid 
• 105542-98-1 1,3-bisiodobicyclo[1.1.1]pentane 

Downstream Products

• 156329-79-2 3-Phenyl-bicyclo[1.1.1]pentane-1-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 112043-92-2 1-bromo-3-phenylbicyclo<1.1.1>pentane 
• 156329-87-2 1-phenyl-3-(trimethylsilyl)bicyclo<1.1.1>pentane 
• 156329-64-5 1-bromo-3-(p-nitrophenyl)bicyclo<1.1.1>pentane 
• 156329-81-6 3-(4-Nitro-phenyl)-bicyclo[1.1.1]pentane-1-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 83249-22-3 3-[1-Methyl-1-(4-nitro-benzoyloxy)-ethyl]-bicyclo[1.1.1]pentane-1-carboxylic acid methyl ester 
• 83249-21-2 4-Nitro-benzoic acid 1-methyl-1-(3-phenyl-bicyclo[1.1.1]pent-1-yl)-ethyl ester 
• 83249-06-3 3-acetoxy-1-phenylbicyclo<1.1.1>pentane 
• 83249-18-7 3-phenyl-1-(2-hydroxy-2-propyl)bicyclo<1.1.1>pentane 
• 83249-10-9 3‐(methoxycarbonyl)bicyclo[1.1.1]pentane‐1‐carboxylic acid 
• 83249-14-3 methyl 3-bromobicyclo<1.1.1>pentane-1-carboxylate 
• 56842-95-6 bicyclo<1.1.1>pentane-1,3-dicarboxylic acid 

Relevant articles and documents

ANALGESIC COMPOUNDS

Disclosed herein are compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.

COMPOUNDS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.

Formation and reactions of bicyclo[1.1.1]pentyl-1 cations

The ionization of 1-bicyclo[1.1.1]pentyl halides was shown to initially form the 1,3-bridged bicyclo[1.1.1]pentyl-l cation. It appears to be a transition state that leads to the bicyclo[1.1.0]butyl-1-carbinyl cation which can be trapped with azide ion and