83253-77-4

Basic information

• Product Name: 3-(4-methoxyphenyl)-5,5-dimethyl-4-phenylfuran-2(5H)-one
• Synonyms: 3-(4-methoxyphenyl)-5,5-dimethyl-4-phenylfuran-2(5H)-one
• CAS NO: 83253-77-4
• Molecular Weight: 294.35
• Mol File: 83253-77-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxyphenyl)-5,5-dimethyl-4-phenylfuran-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-5,5-dimethyl-4-phenylfuran-2(5H)-one(83253-77-4)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-5,5-dimethyl-4-phenylfuran-2(5H)-one(83253-77-4)

Safety Data

• Hazardous Substances Data: 83253-77-4(Hazardous Substances Data)

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 7473-98-5 2-hydroxy-2-methylpropiophenone 
• 104-47-2 p-methoxybenzylnitrile 
• 14491-02-2 2,2-dimethyl-3-phenyl-2H-azirine 
• 83253-71-8 (3,3-Dimethyl-2-phenyl-aziridin-2-yl)-(4-methoxy-phenyl)-acetic acid 
• 83253-86-5 4-Amino-3-(4-methoxy-phenyl)-5,5-dimethyl-4-phenyl-dihydro-furan-2-one 
• 19924-43-7 3-methoxyphenylacetonitrile 
• 10409-54-8 2-bromo-2-methyl-1-phenyl-propan-1-one 

Relevant articles and documents

Copper-Catalyzed [2 + 3] Cyclization of α-Hydroxyl Ketones and Arylacetonitriles: Access to Multisubstituted Butenolides and Oxazoles

A copper-catalyzed [2 + 3] formal cyclization reaction between α-hydroxyl ketones and arylacetonitriles has been developed. The reaction outcome was ultimately dependent on the structure of the α-hydroxy ketones employed. Tertiary α-hydroxy ketones gave 3,4,5,5-tetrasubstituted butenolides as the sole products, while secondary α-hydroxy ketones furnished 2,4,5-trisubstituted oxazoles selectively. This method has many advantages, such as the use of easily available substrates, broad substrate scope, good functional tolerance, and milder reaction conditions.

ADDITION DE REACTIFS AMBIDENTS DIMETALLIQUES A LA DOUBLE LIAISON AZIRINIQUE

The Ivanov magnesium reagents obtained from aryl-acetic acids add to 3,3-dimethyl-2-phenyl azirine to give β-aziridino acids 4, which are easily transformed into 4-amino lactones 10 and further into butenolides 11.If sodium is substituted for magnesium th