83253-79-6

Basic information

• Product Name: 5,5-dimethyl-4-phenyl-3-(thiophen-2-yl)furan-2(5H)-one
• Synonyms: 5,5-dimethyl-4-phenyl-3-(thiophen-2-yl)furan-2(5H)-one
• CAS NO: 83253-79-6
• Molecular Weight: 270.352
• Mol File: 83253-79-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5,5-dimethyl-4-phenyl-3-(thiophen-2-yl)furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-dimethyl-4-phenyl-3-(thiophen-2-yl)furan-2(5H)-one(83253-79-6)
• EPA Substance Registry System: 5,5-dimethyl-4-phenyl-3-(thiophen-2-yl)furan-2(5H)-one(83253-79-6)

Safety Data

• Hazardous Substances Data: 83253-79-6(Hazardous Substances Data)

Upstream product

• 20893-30-5 2-cyanomethylthiophene 
• 7473-98-5 2-hydroxy-2-methylpropiophenone 
• 14491-02-2 2,2-dimethyl-3-phenyl-2H-azirine 
• 1918-77-0 Thiophene-2-acetic acid 
• 83253-74-1 (3,3-Dimethyl-2-phenyl-aziridin-2-yl)-thiophen-2-yl-acetic acid 

Relevant articles and documents

Copper-Catalyzed [2 + 3] Cyclization of α-Hydroxyl Ketones and Arylacetonitriles: Access to Multisubstituted Butenolides and Oxazoles

A copper-catalyzed [2 + 3] formal cyclization reaction between α-hydroxyl ketones and arylacetonitriles has been developed. The reaction outcome was ultimately dependent on the structure of the α-hydroxy ketones employed. Tertiary α-hydroxy ketones gave 3,4,5,5-tetrasubstituted butenolides as the sole products, while secondary α-hydroxy ketones furnished 2,4,5-trisubstituted oxazoles selectively. This method has many advantages, such as the use of easily available substrates, broad substrate scope, good functional tolerance, and milder reaction conditions.