83256-18-2

Basic information

• Product Name: (E)-2-(2,6-dimethoxy-5-nitropyrimidin-4-yl)-N,N-dimethylethenamine
• Synonyms: (E)-2-(2,6-Dimethoxy-5-nitropyrimidin-4-yl)-N,N-dimethylethenamine; [2-(2,6-Dimethoxy-5-nitro-pyrimidin-4-yl)-vinyl]-dimethyl-amine; ethenamine, 2-(2,6-dimethoxy-5-nitro-4-pyrimidinyl)-N,N-dimethyl-, (E)-
• CAS NO: 83256-18-2
• Molecular Formula: C₁₀H₁₄N₄O₄
• Molecular Weight: 254.2426
• Mol File: 83256-18-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 450.3°C at 760 mmHg
• Flash Point: 226.2°C
• Density: 1.268g/cm³
• Vapor Pressure: 2.66E-08mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: (E)-2-(2,6-dimethoxy-5-nitropyrimidin-4-yl)-N,N-dimethylethenamine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(2,6-dimethoxy-5-nitropyrimidin-4-yl)-N,N-dimethylethenamine(83256-18-2)
• EPA Substance Registry System: (E)-2-(2,6-dimethoxy-5-nitropyrimidin-4-yl)-N,N-dimethylethenamine(83256-18-2)

Safety Data

• Hazardous Substances Data: 83256-18-2(Hazardous Substances Data)

Upstream product

• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 
• 30561-09-2 5-nitro-2,4-dimethoxy-6-methylpyrimidine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 

Downstream Products

• 97203-58-2 p-nitrophenylazo-5-nitro-2,6-dimethoxy-4-pyrimidinylacetaldehyde 
• 97189-41-8 5-nitro-2,4-dimethoxy-6-(2-benzylaminovinyl)pyrimidine 
• 86445-10-5 5-nitro-2,4-dimethoxy-6-phenacylpyrimidine 
• 84538-40-9 2,4-dimethoxy-5H-pyrrolo<3,2-d>pyrimidine 

Relevant articles and documents

Synthetic Strategies toward the Synthesis of 2,4-Dimethoxypyrrolopyrimidine

Two approaches to prepare 2,4-dimethoxypyrrolopyrimidine (1) are described. 2,4-Dimethoxy-6-methyl-5-nitropyrimidine (2) was converted to 6-(cyanomethyl)-2,4-dimethoxy-5-nitropyrimidine (6) in two steps.Subsequent catalytic hydrogenation of 6 produced 1.In a second approach, 2 was formylated, giving rise to 6--2,4-dimethoxy-5-nitropyrimidine (7).Hydrogenation of 7 resulted in the formation of 1.Reduction of 2 provided 5-amino-2,4-dimethoxy-6-methylpyrimidine (10).Reaction of compound 10 with triethyl orthoformate produced 2,4-dimethoxy-5--6-methylpyrimidine (11).Reaction of 11 with lithium diisopropylamide gave 2,4-dimethoxy-5-isocyano-6-methylpyrimidine (12).