83343-23-1

Basic information

• Product Name: N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
• Synonyms: N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
• CAS NO: 83343-23-1
• Molecular Weight: 267.371
• Mol File: 83343-23-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine(83343-23-1)
• EPA Substance Registry System: N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine(83343-23-1)

Safety Data

• Hazardous Substances Data: 83343-23-1(Hazardous Substances Data)

Upstream product

• 3469-26-9 2,7-Dimethoxynaphthalene 
• 582-17-2 2,7-Dihydroxynaphthalene 
• 4133-34-0 7-methoxyl-2-tetralone 
• 100-46-9 benzylamine 

Downstream Products

• 4003-89-8 2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene 
• 3880-78-2 7-Methoxy-1,2,3,4-tetrahydro-(2R)-2-naphthaleneamine hydrochloride 
• 1355593-17-7 methyl 7-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylate 
• 1355592-91-4 methyl 7-[(3-methoxyphenyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylate 
• 194785-79-0 7-hydroxy-1,2,3,4-tetrahydro-2-naphthylamine hydrobromide 
• 194785-79-0 (7S)-7-amino-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide 
• 121216-42-0 (2S)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine 
• 121216-43-1 (2R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine 
• 220640-10-8 (7R)-7-amino-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide 
• 121251-89-6 (R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (S)-mandelate 
• 121251-88-5 (S)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (S)-mandelate 
• 1274817-11-6 N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride 
• 1274816-90-8 N-[(2R)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide 

Relevant articles and documents

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

This invention provides compounds of formula (I): wherein R1, R1b, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.

PREPARATION OF AMINOTETRALIN COMPOUNDS

The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.

2-Amido-8-methoxytetralins: A Series of Nonindolic Melatonin-like Agents

A series of unsubstituted and methoxy-substituted 2-amidotetralins (4a-q) was prepared and evaluated for their ability to complete for 2-iodomelatonin binding to chicken retinal membranes and for their potency to inhibit the calcium-dependent release of dopamine from rabbit retina.The lead compound, 2-acetamido-8-methoxytetralin (4j), showed a moderate affinity (Ki = 46 nM) and potency (IC50 = 1.4 nM) at the melatonin receptor.The structural requirements necessary for optimal agonistic activity at the melatonin receptor are as follows.First, the amido group, which should have a small, nonbranched alkyl group, is essential for affinity, and second, the methoxy substituent at the 8-position of the 2-amidotetralin ring is essential for optimal agonistic activity at the melatonin receptor.We concluded that this series of unsubstituted and methoxy-substituted 2-amidotetralins constitutes a class of nonindolic melatonin-like agents that can be used as pharmacological tools to further characterize melatonin receptors and to elucidate the mode of action of melatonin.