833451-03-9Relevant articles and documents
An efficient synthesis of 4,6-substituted pyrrolo[3,2-d]pyrimidines by silver-catalyzed cyclization of acetylene amine
Xie, Rui,Hu, Ying,Wan, Huixin,Hu, Yanwei,Chen, Shaohua,Zhang, Shilei,Zhang, Yinan
supporting information, p. 2418 - 2421 (2016/05/19)
A silver catalyzed cyclization of acetylene amine was developed to synthesize 4,6-substituted pyrrolo[3,2-d]pyrimidine, a bioactive isosteric scaffold of purine. Starting from simple commercially available acetylenes and pyrimidines, the method was found
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase
Smith II, Leon,Wong, Wai C.,Kiselyov, Alexander S.,Burdzovic-Wizemann, Sabina,Mao, Yunyu,Xu, Yongjiang,Duncton, Matthew A.J.,Kim, Ki,Piatnitski, Evgueni L.,Doody, Jacqueline F.,Wang, Ying,Rosler, Robin L.,Milligan, Daniel,Columbus, John,Balagtas, Chris,Lee, Sui Ping,Konovalov, Andrey,Hadari, Yaron R.
, p. 5102 - 5106 (2007/10/03)
Novel tricyclic derivatives containing an oxazepine, thiazepine, or diazepine ring were studied for their EGFR tyrosine kinase inhibitory activity. While the oxazepines were in general more potent than thiazepines, the diazepines displayed somewhat differ
