83352-51-6

Basic information

• Product Name: 11-chloro-4,6-dihydroxy-3,4,4a,12a-tetrahydrotetracene-2,5,12(1H)-trione
• CAS NO: 83352-51-6
• Molecular Formula: C₁₈H₁₃ClO₅
• Molecular Weight: 344.7458
• Mol File: 83352-51-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 674.3°C at 760 mmHg
• Flash Point: 361.6°C
• Density: 1.572g/cm³
• Vapor Pressure: 4.22E-19mmHg at 25°C
• Refractive Index: 1.715
• CAS DataBase Reference: 11-chloro-4,6-dihydroxy-3,4,4a,12a-tetrahydrotetracene-2,5,12(1H)-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 11-chloro-4,6-dihydroxy-3,4,4a,12a-tetrahydrotetracene-2,5,12(1H)-trione(83352-51-6)
• EPA Substance Registry System: 11-chloro-4,6-dihydroxy-3,4,4a,12a-tetrahydrotetracene-2,5,12(1H)-trione(83352-51-6)

Safety Data

• Hazardous Substances Data: 83352-51-6(Hazardous Substances Data)

Usage

Chemical class

Tetracycline antibiotics

Derived from

Natural antibiotic tetracycline

Function

Treats a wide range of bacterial infections

Structural features

Presence of chlorine atom and hydroxyl groups

Antibiotic activity

Inhibits bacterial growth by preventing protein synthesis

Usage

Often used in combination with other medications

Forms available

Capsules, tablets, and topical preparations

Safety

Generally considered safe and effective when used as directed

Mechanism of action

Binds to the 30S ribosomal subunit of bacteria, preventing the attachment of aminoacyl-tRNA to the mRNA-ribosome complex, thus inhibiting protein synthesis

Resistance

Can contribute to bacterial resistance if not used properly

Administration

Oral or topical, depending on the specific formulation

Precautions

May have drug interactions and contraindications, so it's important to follow healthcare professional's guidance

Side effects

Can include gastrointestinal issues, photosensitivity, and fungal infections, among others

Storage

Should be stored in a cool, dry place, away from light, and out of reach of children

Expiration date

Has a specific expiration date, after which the effectiveness may be reduced or the drug may become unsafe to use

Upstream product

• 83352-50-5 11-Chloro-6-hydroxy-4-trimethylsilanyloxy-3,4,4a,12a-tetrahydro-1H-naphthacene-2,5,12-trione 
• 41099-45-0 9-chloro-10-hydroxyanthracene-1,4-dione 

Relevant articles and documents

ANTHRACYCLINES. CYCLOADDITIONS OF 9-CHLORO-10-HYDROXY-1,4-ANTHRAQUINONE WITH VARIOUS BUTA-1,3-DIENES

The Diels-Alder type cycloaddition of several substituted buta-1,3-dienes with 9-chloro-10-hydroxy-1,4-anthraquinone (10) affords an efficient, regiospecific access in two steps to tetracyclic ketones (12-14) which have been investigated as intermediates for the synthesis of anthracycline derivatives.Butadienes with a less asymmetric ?-electron distribution than 9 give lower regiospecificity in cycloadditions with 10.Depending on the substituents in the used butadiene, the obtained cycloadducts are transformed under the reaction circumstances into the aromatized products (15-20).