83450-57-1

Basic information

• Product Name: ((S)-1-{(S)-1-[(S)-1-({[(R)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-4-guanidino-butyl)-carbamic acid tert-butyl ester
• CAS NO: 83450-57-1
• Molecular Weight: 942.152
• Mol File: 83450-57-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((S)-1-{(S)-1-[(S)-1-({[(R)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-4-guanidino-butyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-1-{(S)-1-[(S)-1-({[(R)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-4-guanidino-butyl)-carbamic acid tert-butyl ester(83450-57-1)
• EPA Substance Registry System: ((S)-1-{(S)-1-[(S)-1-({[(R)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-4-guanidino-butyl)-carbamic acid tert-butyl ester(83450-57-1)

Safety Data

• Hazardous Substances Data: 83450-57-1(Hazardous Substances Data)

Upstream product

• 4530-20-5 BOC-glycine 
• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 5241-64-5 Boc-D-Trp-OH 

Downstream Products

• 81039-84-1 H-Arg-Phe-Phe-Gly-D-Trp-Met-NH₂ 

Relevant articles and documents

Synthesis and Biological Activities of Substance P Antagonists

Several substance P analogues containing various D-amino acid modifications have been synthesized by the solid-phase procedure, detached from the solid support by ammonolysis, and purified by gel filtration combined with reversed-phase chromatography.Three compounds were fair to very potent competitive antagonists of substance P on three bioassays, i.e., guinea pig ileum, rabbit mesenteric vein, and guinea pig trachea. 6,D-Trp10>SP(6,11) is a reasonable antagonist in all three bioassays and 4,D-Trp7,9>SP(4-11) is a very potent competitive antagonist with pA2 values ranging around 6.0.