835-09-6

Basic information

• Product Name: (2-bromo-5-chlorophenyl)(phenyl)methanone
• CAS NO: 835-09-6
• Molecular Formula: C₁₃H₈BrClO
• Molecular Weight: 295.559
• Mol File: 835-09-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 382.9°C at 760 mmHg
• Flash Point: 185.4°C
• Density: 1.51g/cm³
• Vapor Pressure: 4.58E-06mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: (2-bromo-5-chlorophenyl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromo-5-chlorophenyl)(phenyl)methanone(835-09-6)
• EPA Substance Registry System: (2-bromo-5-chlorophenyl)(phenyl)methanone(835-09-6)

Safety Data

• Hazardous Substances Data: 835-09-6(Hazardous Substances Data)

Usage

General Description

(2-bromo-5-chlorophenyl)(phenyl)methanone, also known as Bromochlorophenylphenylketone, is a chemical compound with the molecular formula C13H8BrClO. It is a white to off-white solid that is insoluble in water but soluble in organic solvents. The compound has applications in organic synthesis and pharmaceutical research, and it is often used as an intermediate in the production of various pharmaceuticals and agrochemicals. The (2-bromo-5-chlorophenyl)(phenyl)methanone is a versatile building block for the synthesis of a wide range of bioactive compounds, making it a valuable reagent in the pharmaceutical industry. It is important to handle this chemical with proper safety precautions due to its potential hazards.

Upstream product

• 42860-16-2 2-bromo-5-chlorobenzoyl chloride 
• 71-43-2 benzene 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 100-58-3 phenylmagnesium bromide 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 21739-93-5 2-bromo-5-chlorobenzoic acid 
• 105901-09-5 (2-bromo-5-chlorophenyl)(phenyl)methanol 

Downstream Products

• 100397-76-0 2-benzyl-1-bromo-4-chlorobenzene 
• 105901-09-5 (2-bromo-5-chlorophenyl)(phenyl)methanol 
• 1043937-11-6 (5-chloro-2-piperazin-1-yl-phenyl)-phenyl-methanone 
• 37119-07-6 6-chloro-3,4-diphenylquinolin-2(1H)-one 
• 109394-17-4 8-chloro-6-phenylphenanthridine 

Relevant articles and documents

Palladium(II)-catalyzed Intermolecular Cascade Cyclization of Methylenecyclopropanes with Aromatic Alkynes: Construction of Spirocyclic Compounds Containing Indene and 1,2-Dihydronaphthalene Moieties

A palladium(II)-catalyzed intermolecular cascade cyclization of methylenecyclopropanes with aromatic alkynes is reported in this paper. The reaction involves a migratory insertion of alkyne, an intramolecular Heck-type reaction, and β-H elimination, providing a series of spirocyclic compounds containing indene and 1,2-dihydronaphthalene moieties in moderate to excellent yields upon heating.

One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.

1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.