836619-77-3

Basic information

• Product Name: N-Boc-3-bromo-4-fluoroaniline
• Synonyms: N-Boc-3-bromo-4-fluoroaniline;(3-Bromo-4-fluoro-phenyl)-carbamic acid tert-butyl ester
• CAS NO: 836619-77-3
• Molecular Formula: C₁₁H₁₃BrFNO₂
• Molecular Weight: 290
• Mol File: 836619-77-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-Boc-3-bromo-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-3-bromo-4-fluoroaniline(836619-77-3)
• EPA Substance Registry System: N-Boc-3-bromo-4-fluoroaniline(836619-77-3)

Safety Data

• Hazardous Substances Data: 836619-77-3(Hazardous Substances Data)

Usage

General Description

N-Boc-3-bromo-4-fluoroaniline is a chemical compound with the formula C13H15BrFN2O2. It is a substituted aniline derivative with a tert-butoxycarbonyl (Boc) protecting group on the amino group. The compound contains a bromine atom and a fluorine atom attached to the benzene ring, making it a halogenated aromatic compound. It is commonly used as a building block in organic synthesis, particularly in the pharmaceutical industry for the production of various drugs and drug intermediates. Its unique structure and reactivity make it a valuable intermediate in the synthesis of complex organic molecules. Additionally, its Boc protecting group can be removed under mild conditions, making it a versatile tool in organic chemistry.

Upstream product

• 1007-16-5 3-bromo-4-fluorobenzoic acid 
• 75-65-0 tert-butyl alcohol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1257294-51-1 6-bromo-5-fluoro-pyridin-2-ylamine 
• 656-64-4 3-bromo-4-fluoroaniline 

Downstream Products

• 1269815-47-5 (3-bromo-4-fluorophenyl)-(tetrahydropyran-4-ylmethyl)carbamic acid tert-butyl ester 
• 656-64-4 3-bromo-4-fluoroaniline 
• 902121-19-1 tert-butyl (3-anilino-4-fluorophenyl)carbamate 

Relevant articles and documents

Mild deprotection of the: N-tert -butyloxycarbonyl (N -Boc) group using oxalyl chloride

We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90percent. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy. This journal is

PHENYL-HETEROARYL AMINE COMPOUNDS AND THEIR USES

The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I, and pharmaceutical compositions comprising such compounds

QUINOLONE DERIVATIVE OR SALT THEREOF

A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically acceptable salt thereof useful as a platelet aggregation inhibitor.