83671-43-6

Basic information

• Product Name: N-methyl-4-(N,N-dimethylamino)benzylamine
• Synonyms: N-methyl-4-(N,N-dimethylamino)benzylamine;N-Methyl-4-(dimethylamino)benzylamine Dihydrochloride;Dimethyl-(4-methylaminomethyl-phenyl)-amine;4-(Dimethylamino)-N-methylbenzenemethanamine;Benzenemethanamine, 4-(dimethylamino)-N-methyl-;Nmdmaba;4-(DiMethylaMino)-N-Methyl-benzylaMine;4-(Dimethylamino)-N-methylbenzylamine, N-{4-[(Methylamino)methyl]phenyl}dimethylamine
• CAS NO: 83671-43-6
• Molecular Formula: C₁₀H₁₆N₂
• Molecular Weight: 164.25
• Product Categories: Amines and Anilines
• Mol File: 83671-43-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 252.1 °C at 760 mmHg
• Flash Point: 101.9 °C
• Appearance: /
• Density: 0.971 g/cm³
• Vapor Pressure: 0.0198mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-methyl-4-(N,N-dimethylamino)benzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-4-(N,N-dimethylamino)benzylamine(83671-43-6)
• EPA Substance Registry System: N-methyl-4-(N,N-dimethylamino)benzylamine(83671-43-6)

Safety Data

• Hazardous Substances Data: 83671-43-6(Hazardous Substances Data)

Usage

General Description

N-methyl-4-(N,N-dimethylamino)benzylamine, also known as N,N-dimethyl-4-(phenylmethyl)aniline, is a chemical compound with a molecular formula C13H18N2. It is an organic compound with a benzylamine backbone and a dimethylamino group, and it is commonly used as a reagent in organic chemistry. N-methyl-4-(N,N-dimethylamino)benzylamine is a pale yellow to light brown liquid with a strong, amine-like odor. It is soluble in water and organic solvents, and it is often used as a catalyst or intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. N-methyl-4-(N,N-dimethylamino)benzylamine is also known for its ability to act as a ligand in coordination chemistry, making it useful for various applications in chemical research and industry.

InChI:InChI=1/C10H16N2/c1-11-8-9-4-6-10(7-5-9)12(2)3/h4-7,11H,8H2,1-3H3/p+1

Upstream product

• 877-79-2 4-(dimethylamino)-N-methylbenzylimine 
• 593-51-1 methylamine hydrochloride 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 74-89-5 methylamine 

Downstream Products

• 112781-04-1 3-[N-methyl-N-(4-dimethylaminobenzyl)]aminopropiophenone 
• 1041612-42-3 N₁-(3-chlorophenyl)-N₆-(4-(dimethylamino)benzyl)-N₆-methyl-2,3-dihydro-1H-indene-1,6-diamine 
• 1181882-36-9 N-(4-(dimethylamino)benzyl)-N,1-dimethyl-1H-indole-3-carboxamide 
• 1326422-72-3 N-(4-(dimethylamino)benzyl)-N-methyl-4-nitrobenzamide 
• 1469886-91-6 N-(4-(dimethylamino)benzyl)-N-methyldecanamide 
• 81054-32-2 4-(N-Methyl-benzamidomethyl)-N,N-dimethylanilin 
• 1179751-12-2 4-bromo-N-(4-(dimethylamino)benzyl)-N-methylbenzamide 
• 1469886-88-1 4-acetyl-N-(4-(dimethylamino)benzyl)-N-methylbenzamide 
• 1469886-89-2 4-benzoyl-N-(4-(dimethylamino)benzyl)-N-methylbenzamide 
• 1326101-69-2 N-(4-(dimethylamino)benzyl)-3,4-dimethoxy-N-methylbenzamide 
• 1469886-90-5 N-(4-(dimethylamino)benzyl)-N-methyl-2-phenylacetamide 
• 75288-12-9 N-(4-(dimethylamino)benzyl)-N-methylacetamide 
• 415929-57-6 N,N-dimethyl-4-((methyl(phenethyl)amino)methyl)aniline 
• 29235-08-3 4-((benzyl(methyl)amino)methyl)-N,N-dimethylaniline 

Relevant articles and documents

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT

A series of 12 new dibemethin (N-benzyl-N-methyl-1-phenylmethanamine) derivatives bearing an N-aminomethyl group attached to the one phenyl ring and an H, Cl, OCH3 or N(CH3)2 group on the other have been synthesized. These compounds all showed strong chloroquine chemosensitizing activity, comparable to verapamil, when present at 1 μM in an in vitro culture of the chloroquine-resistant W2 strain of the human malaria parasite, Plasmodium falciparum. Their N-formylated derivatives also exhibited resistance-reversing activity, but only at substantially higher IC10 concentrations. A number of the dibemethin derivatives were shown to inhibit chloroquine transport via the parasite's 'chloroquine resistance transporter' (PfCRT) in a Xenopus laevis oocyte expression system. The reduced resistance-reversing activity of the formylated compounds relative to their free amine counterparts can probably be ascribed to two factors: decreased accumulation of the formylated dibemethins within the parasite's internal digestive vacuole (believed to be the site of action of chloroquine), and a reduced ability to inhibit PfCRT. The resistance-reversing activity of the compounds described here demonstrates that the amino group need not be attached to the two aromatic rings via a three or four carbon chain as has been suggested by previous QSAR studies. These compounds may be useful as potential side chains for attaching to a 4,7-dichloroquinoline group in order to generate new resistance-reversing chloroquine analogues with inherent antimalarial activity.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.

Endocyclic Nucleophilic Substitution at Tetracoordinate Sulfur(VI)

A search for endocyclic nucleophilic substitution at tetracoordinate sulfur(VI), usually sulfonyl sulfur, was carried out through the use of molecules so constructed that any intramolecular substitution process was forced to proceed through four-, five-,