83674-18-4

Basic information

• Product Name: 7-chloro-N-phenyl-4-quinolinamine
• Synonyms: 7-chloro-N-phenyl-4-quinolinamine
• CAS NO: 83674-18-4
• Molecular Formula: C₁₅H₁₁ClN₂
• Molecular Weight: 254.71424
• Mol File: 83674-18-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-chloro-N-phenyl-4-quinolinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-N-phenyl-4-quinolinamine(83674-18-4)
• EPA Substance Registry System: 7-chloro-N-phenyl-4-quinolinamine(83674-18-4)

Safety Data

• Hazardous Substances Data: 83674-18-4(Hazardous Substances Data)

Upstream product

• 26413-49-0 1-acetyl-7-chloro-2,3-dihydro-1H-quinolin-4-one 
• 86-98-6 4,7-dichloroquinoline 
• 62-53-3 aniline 
• 86-99-7 7-chloro-4-hydroxylquinoline 
• 21617-15-2 7-chloro-1,2,3,4-tetrahydroquinolin-4-one 

Relevant articles and documents

Effects of ferrocenyl 4-(Imino)-1,4-dihydroquinolines on xenopus laevis prophase i-arrested oocytes: Survival and hormonal-induced m-phase entry

Xenopus oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that have been developed as potential anti-cancer agents. One ferrocenyl dihydroquinoline co

Synthesis method of aza-arylamine compound and aza-arylamine compound

The invention provides a synthesis method of an aza-arylamine compound as shown in a formula (I). The synthesis method comprises the following steps: an aza aromatic hydrocarbon compound as shown in aformula (II) reacts with an amine compound as shown in a formula (III) in presence of alkali and under a heating condition, so that u X substituent groups on an A ring of the compound as shown in theformula (II) are substituted by NRR in the compound as shown in the formula (III), and the compound as shown in the formula (I) is obtained, wherein A is an aza six-membered aromatic ring or five-membered aromatic ring, and is an independent single ring or is fused with a ring B; X refers to that the A ring has at least n X substituent groups, each X substituent group is independently selected from the group consisting of F, Cl, Br, I, CN, alkoxy of C and alkylthio of C, and n is a positive integer selected from 1-5; and the alkali is one or a mixture of more selected fromof BuOK, BuONa, BuONa, KHMDS, NaHMDS and LiHMDS. The synthesis method provided by the invention does not need the use of transition metal catalysts, is simple and convenient to operate, is economical and practical and is environmentally friendly. In addition, the invention also provides the aza-arylamine compound prepared by the method.

Functionalized acridin-9-yl phenylamines protected neuronal HT22 cells from glutamate-induced cell death by reducing intracellular levels of free radical species

The in vitro neuronal cell death model based on the HT22 mouse hippocampal cell model is a convenient means of identifying compounds that protect against oxidative glutamate toxicity which plays a role in the development of certain neurodegenerative diseases. Functionalized acridin-9-yl-phenylamines were found to protect HT22 cells from glutamate challenge at submicromolar concentrations. The Aryl1-NHAryl2 scaffold that is embedded in these compounds was the minimal pharmacophore for activity. Mechanistically, protection against the endogenous oxidative stress generated by glutamate did not involve up-regulation of glutathione levels but attenuation of the late stage increases in mitochondrial ROS and intracellular calcium levels. The NH residue in the pharmacophore played a crucial role in this regard as seen from the loss of neuroprotection when it was structurally modified or replaced. That the same NH was essential for radical scavenging in cell-free and cell-based systems pointed to an antioxidant basis for the neuroprotective activities of these compounds.