837364-89-3 Usage
General Description
2,4-Difluoro-5-iodo-pyridine is a halogenated pyridine derivative often used in organic synthesis and pharmaceutical research due to its reactivity. This chemical compound belongs to the group of organofluorines and organoiodines and specifically to the family of pyridines. Its molecular formula is C5H2F2IN and its molecular weight is 259.98 g/mol. Additionally, it possesses properties such as high stability and high boiling point which makes it useful in specific chemical reactions. It should be handled with care due to its reactivity and potential toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 837364-89-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,3,7,3,6 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 837364-89:
(8*8)+(7*3)+(6*7)+(5*3)+(4*6)+(3*4)+(2*8)+(1*9)=203
203 % 10 = 3
So 837364-89-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H2F2IN/c6-3-1-5(7)9-2-4(3)8/h1-2H
837364-89-3Relevant articles and documents
Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: The trialkylsilyl trick
Schlosser, Manfred,Bobbio, Carla,Rausis, Thierry
, p. 2494 - 2502 (2007/10/03)
(Chemical Equation Presented) 2,4-Difluoropyridine, 2,4-dichloropyridine, 2,4,6-trifluoropyridine, 2,4,6-trichloropyridine and 2,3,4,6-tetrafluoropyridine react with standard nucleophiles exclusively at the 4-position under halogen displacement. However, the regioselectivity can be completely reversed if a trialkylsilyl group is introduced in the 5-position of the 2,4-dihalopyridines or in the 3-position of the 2,4,6-trihalopyridines or 2,3,4,6-tetrahalopyridine. Then only the halogen most remote from the bulky silyl unit (at the 2-position in the case of the 2,4-halopyridines, at the 6-position with the other substrates) gets involved in the exchange process. After removal of the silyl protective group the nucleophile is invariably found to occupy the nitrogen-neighboring position.
