837407-31-5

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[3-(dimethylamino)-2-methylpropyl]-
• CAS NO: 837407-31-5
• Molecular Formula: C14H18N2O2
• Molecular Weight: 246.309
• Mol File: 837407-31-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[3-(dimethylamino)-2-methylpropyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[3-(dimethylamino)-2-methylpropyl]-(837407-31-5)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[3-(dimethylamino)-2-methylpropyl]-(837407-31-5)

Safety Data

• Hazardous Substances Data: 837407-31-5(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 6105-72-2 N¹,N¹,2-trimethylpropane-1,3-diamine 

Relevant articles and documents

Muscarinic allosteric enhancers of ligand binding: Pivotal pharmacophoric elements in hexamethonio-type agents

Bisphthalimidopropyl-substituted hexamethonio compounds have been established as allosteric modulators of ligand binding to muscarinic acetylcholine receptors. Enhancers of ligand binding are of special interest. This study aimed to unravel the structural elements inducing positive cooperativity with the binding of an antagonist. [3H]-N- methylscopolamine binding to muscarinic M2 receptors was measured in porcine heart homogenates. Dimethylation, but not monomethylation, of the lateral propyl chain in combination with an affinity increasing aromatic imide moiety, such as a 5-methylphthalimide and naphthalimide, on the same side of the molecule shifts the cooperativity toward positive values, resulting in enhancers of antagonist binding. Thus, lateral side chain dimethylation is a pivotal pharmacophoric element for positive cooperativity in hexamethonio-type muscarinic allosteric agents.