83741-35-9

Basic information

• Product Name: 1H-Benzimidazole,4-bromo-(9CI)
• Synonyms: 1H-Benzimidazole,4-bromo-(9CI);4-Bromo-1H-benzimidazole;4-bromo-1H-benzo[d]imidazole;7-Bromo-1H-benzo[d]imidazole;4-Bromobenzimidazole;7-Bromo-1H-benzimidazole;4-broMo-1H-1,3-benzodiazole;1H-BenziMidazole,7-broMo-
• CAS NO: 83741-35-9
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.035
• Product Categories: BENZIMIDAZOLE
• Mol File: 83741-35-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 168℃
• Boiling Point: 417.4 °C at 760 mmHg
• Flash Point: 206.2 °C
• Appearance: /
• Density: 1.770
• Vapor Pressure: 8.63E-07mmHg at 25°C
• Refractive Index: 1.727
• Storage Temp.: Room temperature.
• PKA: 11.19±0.30(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole,4-bromo-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,4-bromo-(9CI)(83741-35-9)
• EPA Substance Registry System: 1H-Benzimidazole,4-bromo-(9CI)(83741-35-9)

Safety Data

• Hazardous Substances Data: 83741-35-9(Hazardous Substances Data)

Usage

Uses

7-Bromo-1H-benzo[d]imidazole is used in the preparation of antibody drug conjugates with NAMPT inhibitors for use in treatment of cancer.

InChI:InChI=1/C7H5BrN2/c8-5-2-1-3-6-7(5)10-4-9-6/h1-4H,(H,9,10)

Upstream product

• 64-18-6 formic acid 
• 7138-15-0 3-bromo-2-nitrophenylamine 
• 16712-16-6 ammonium formate 
• 59255-95-7 2-bromo-6-nitroaniline 
• 1575-36-6 3-bromobenzene-1,2-diamine 
• 122-51-0 orthoformic acid triethyl ester 
• 19613-76-4 1-bromo-2,3-dinitro-benzene 

Downstream Products

• 247083-12-1 4-(piperazin-1-yl)-1-trityl-1H-benzo[d]imidazole 
• 1580483-62-0 7-(1H-benzo[d]imidazol-4-yl)-N-(3,4,5-trimethoxyphenyl) benzo[d]oxazol-2-amine 
• 1370001-86-7 5-(1-(2,4-difluorophenyl)-1H-benzo[d]imidazol-4-yl)pyrimidin-4-amine 
• 1370001-72-1 1-benzyl-4-(4-methylpyridin-3-yl)-1H-benzo[d]imidazole 

Relevant articles and documents

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Microwave use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds method

The invention discloses a microwave the use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds, in the aqueous phase under microwave conditions adding benzoic amidine compound under alkaline condition [...] into benzimidazole reaction, invention an environment-friendly, the operation is simple, cheap and safe, efficient process for preparing benzimidazole method. Compared with the prior art, this method not only can be applied to a large number of functional groups, the productive rate is high, few by-products, and the operation is simple, safe, low cost, environmental protection; .

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described