83781-69-5Relevant articles and documents
Synthesis of 1,2,3,4-tetrahydroisoquinolines by microreactor-mediated thermal isomerization of laterally lithiated arylaziridines
Giovine, Arianna,Musio, Biagia,Degennaro, Leonardo,Falcicchio, Aurelia,Nagaki, Aiichiro,Yoshida, Jun-Ichi,Luisi, Renzo
supporting information, p. 1872 - 1876 (2013/04/10)
Flow chemistry: A flow-microreactor-mediated synthesis of 1,2,3,4-tetrahydroisoquinolines (THIQs) is reported (see scheme). Starting from a laterally lithiated aziridine, a tetrahydroisoquinoline lithiated at C4 was generated by thermally induced isomerization. Because the reaction temperature is a crucial parameter, the exquisite thermal control possible in a flow-microreactor system allowed for fast, efficient, and highly reproducible synthesis of functionalized aziridines or THIQs. Copyright