83791-43-9

Basic information

• Product Name: methyl (4S,5R)-5-methyl-2-carbonyloxazolidine-4-carboxylate
• Synonyms: methyl (4S,5R)-5-methyl-2-carbonyloxazolidine-4-carboxylate
• CAS NO: 83791-43-9
• Molecular Weight: 159.142
• Mol File: 83791-43-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: methyl (4S,5R)-5-methyl-2-carbonyloxazolidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (4S,5R)-5-methyl-2-carbonyloxazolidine-4-carboxylate(83791-43-9)
• EPA Substance Registry System: methyl (4S,5R)-5-methyl-2-carbonyloxazolidine-4-carboxylate(83791-43-9)

Safety Data

• Hazardous Substances Data: 83791-43-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 72-19-5 L-threonine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 80465-30-1 N-carboxy 2-amino-2-butenoic acid anhydride 
• 83791-33-7 4-(1-Bromo-ethyl)-4-methoxy-oxazolidine-2,5-dione 
• 163254-35-1 methyl 3-((tert-butoxycarbonyl)amino)butanoate 
• 3373-59-9 allo-Thr-OMe 
• 83791-38-2 5-methyl-2-oxo-2,3-dihydro-1,3-oxazole-4-carboxylic acid methyl ester 
• 332-25-2 4-(trifluoromethoxy)benzonitrile 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 1195-20-6 (5R,4S)-5-methyl-2-oxazolidinone-4-carboxylic acid 

Downstream Products

• 128062-14-6 C₅H₈N₂O₃ 
• 60538-19-4 N-(tert-butoxycarbonyl)-l-threonine methyl ester 

Relevant articles and documents

Visible-Light-Mediated Liberation and In Situ Conversion of Fluorophosgene

The first example for the photocatalytic generation of a highly electrophilic intermediate that is not based on radical reactivity is reported. The single-electron reduction of bench-stable and commercially available 4-(trifluoromethoxy)benzonitrile by an organic photosensitizer leads to its fragmentation into fluorophosgene and benzonitrile. The in situ generated fluorophosgene was used for the preparation of carbonates, carbamates, and urea derivatives in moderate to excellent yields via an intramolecular cyclization reaction. Transient spectroscopic investigations suggest the formation of a catalyst charge-transfer complex-dimer as the catalytic active species. Fluorophosgene as a highly reactive intermediate, was indirectly detected via its next downstream carbonyl fluoride intermediate by NMR. Furthermore, detailed NMR analyses provided a comprehensive reaction mechanism including a water dependent off-cycle equilibrium.

Crystal form containing triple-fused-ring derivative free alkali and pharmaceutical composition thereof

The invention relates to a crystal form containing triple-fused-ring derivative free alkali and a pharmaceutical composition thereof. The invention specifically relates to a crystal form of a compound free alkali with a general formula (I), a preparation method, a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and an application of the crystal form in preparation of drugs for treating PI3K-mediated related diseases.

Pd-catalyzed carboamination of oxazolidin-2-ones: A stereoselective route to trans -2,5-disubstituted pyrrolidines

Palladium-catalyzed carboamination reactions between aryl bromides and 4-(but-3-enyl)-substituted oxazolidin-2-ones are described. These transformations afford bicyclic oxazolidin-2-one derivatives that can be converted to trans-2,5-disubstituted pyrrolid