838-88-0

Basic information

• Product Name: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE
• Synonyms: 4,4’-methylenebis(2-methyl-anilin;4,4’-methylenebis(2-methyl-benzenamin;4,4’-methylenebis(2-methylbenzenamine);4,4’-methylenebis[2-methyl-benzenamin;4,4’-methylenedi-o-toluidin;bis(4-amino-3-methylphenyl)-methan;bis(4-amino-3-methylphenyl)methane;bis-4-amino-3-methylfenylmethan
• CAS NO: 838-88-0
• Molecular Formula: C₁₅H₁₈N₂
• Molecular Weight: 226.32
• EINECS: 212-658-8
• Product Categories: Industrial/Fine Chemicals;Diphenylmethanes (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 838-88-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 155-157 °C
• Boiling Point: 357.94°C (rough estimate)
• Flash Point: 238.9 °C
• Appearance: /
• Density: 0.9543 (rough estimate)
• Vapor Pressure: 1.8hPa at 205.5℃
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.18±0.25(Predicted)
• Water Solubility: Insoluble in water
• BRN: 398069
• CAS DataBase Reference: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE(838-88-0)
• EPA Substance Registry System: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE(838-88-0)

Safety Data

• Hazard Codes: T,N
• Statements: 45-22-43-50/53
• Safety Statements: 53-45-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• RTECS: BY5300000
• F: 10-23
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 838-88-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder. Soluble in ethanol and hot water.

Uses

Different sources of media describe the Uses of 838-88-0 differently. You can refer to the following data:
1. 4,4′-Methylene-bis(2-methylaniline) has been used as a reference standard for the determination of 4,4′-methylene-bis(2-methylaniline) in plastic multilayer food packaging materials by liquid chromatography (LC)-Orbitrap-full scan-high resolution mass spectrometry (HRMS). It may be used as a reference standard for the analysis of 4,4′-methylene-bis(2-methylaniline) in dyes, cosmetics, finger paints and inks for pens and tattoos by LC-MS.
2. 4,4'-Diamino-3,3'-dimethyldiphenylmethane can be used for preparation polyimide and epoxy resin material.

General Description

4,4′-Methylene-bis(2-methylaniline) belongs to the primary aromatic amines (PAAs) family of compounds which are toxic in nature and are probable human carcinogens.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. An eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Upstream product

• 636-21-5 o-toluidine hydrochloride 
• 95-53-4 o-toluidine 
• 91-78-1 1,3,5-triphenylhexahydro-1,3,5-triazine 
• 5293-94-7 bis(chloromethyl)mercury 
• 71893-15-7 C₄H₇ClHgO 
• 7647-01-0 hydrogenchloride 
• 861612-93-3 bis-(4-amino-3-methyl-phenyl)-acetic acid 
• 108-44-1 1-amino-3-methylbenzene 
• 50-00-0 formaldehyd 
• 67-68-5 dimethyl sulfoxide 
• 62001-35-8 N-(1-benzotriazolylmethyl)-2-methylaniline 
• 72621-64-8 2-toluidine 
• 88919-92-0 Methoxymethyl-o-tolyl-amine 
• 54560-77-9 bis(2-methylphenylamino)methane 

Downstream Products

• 122240-79-3 bis-(4-diacetylamino-3-methyl-phenyl)-methane 
• 139-25-3 bis-(4-isocyanato-3-methyl-phenyl)-methane 
• 104398-64-3 bis-(4-benzoylamino-3-methyl-phenyl)-methane 
• 103396-01-6 bis-(4-acetylamino-3-methyl-phenyl)-methane 
• 64497-21-8 2-methylbis-(4-aminophenyl)methane 
• 63861-54-1 4,4',4-triamino-3,3',3-trimethyl-triphenyl-carbenium-chloride 
• 2467-25-6 bis(4-hydroxy-3-methylphenyl)methane 
• 6864-37-5 bis-(4-amino-3-methylcyclohexyl)-methane 
• 46893-31-6 4,4'-diamino-3,3'-dimethyl-benzophenone 
• 122397-61-9 3,3'-dimethyl-4,4'-bis(salicylideneimino)diphenylmethane 
• 35112-57-3 4,4'-diamino-5,5'-dimethyl-2,2'-dinitrodiphenylmethane 
• 84797-73-9 4,4'-diamino-5,3'-dimethyl-2-nitrodiphenylmethane 
• 84797-74-0 4,4'-diamino-5,3'-dimethyl-2,2'-dinitrodiphenylmethane 
• 582303-34-2 4,4'-bis(3-chlorophthalimido)-3,3'-dimethyldiphenylmethane 

Relevant articles and documents

Synthesis of 3,3′-dimethyl-4,4′-diaminodiphenylmethane catalyzed by zeolites replacing mineral acids

Synthesis of 3,3′-dimethyl-4,4′-diaminodiphenylmethane (MDT) from o-tolylamine and formaldehyde over zeolites was investigated. Among the three tested zeolites, Hβ showed higher catalytic activity than HY and HZSM-5 for MDT synthesis. In the case of Hβ as a catalyst, the effects of feed composition, reaction time and temperature on the yield and selectivity of product MDT were further examined to optimize process conditions. In an o-tolylamine:formaldehyde = 8:1 molar ratio, the two-step reaction running at 413 K for 0.5 h and then 433 K for 0.5 h gave the MDT yield of 87.5%.

Continuous preparation of solid acid catalysis 4, the 4 [...] -diamino diphenylmethane derivatives (by machine translation)

The invention discloses a continuous preparation of solid acid catalysis 4, the 4 [...] -diaminodiphenylmethane derivative method, the method to aniline derivatives as raw materials with formaldehyde, in one stage or two stage fixed-bed reactor to conduct the condensation reaction of the solid acid catalysis of the reaction, the reaction liquid airspeed is 2-9h -1, obtain 4, the 4 [...] -diamino diphenylmethane derivatives (MDA, MDT, MOCA). The invention uses a solid acid Hβ, HY, HZSM-5 molecular sieve to replace the hydrochloric acid, the traditional inorganic acid catalyst such as sulfuric acid, the reaction is carried out continuously, the method of the invention process is simple, short reaction time, the productivity is high, high yield, no corrosion to equipment, environmental protection, especially suitable for continuous industrial production. (by machine translation)

Highly regioselective para-methylthiolation/bridging methylenation of arylamines promoted by NH4I

Aryl methyl thioethers and methylene-bridged arylamines were synthesized via highly regioselective para-methylthiolation/bridging methylenation of arylamines using DMSO as the methylthio or methylene source in the presence of NH4I under metal-free conditions. For the substrates with both electron-donating and electron-withdrawing substituents, the reaction proceeded smoothly and gave moderate to good yields.