83896-44-0

Basic information

• Product Name: 18α-Glycylrrhizin
• Synonyms: [(18α)-20β-Carboxy-11-oxo-30-norolean-12-en-3β-yl]2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid;18α-Glycylrrhizin;18α-Glycyrrhizin;18α-Glycyrrhizinic acid
• CAS NO: 83896-44-0
• Molecular Formula: C₄₂H₆₂O₁₆
• Molecular Weight: 822.93208
• Mol File: 83896-44-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 971.4°C at 760 mmHg
• Flash Point: 288.1°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 18α-Glycylrrhizin(CAS DataBase Reference)
• NIST Chemistry Reference: 18α-Glycylrrhizin(83896-44-0)
• EPA Substance Registry System: 18α-Glycylrrhizin(83896-44-0)

Safety Data

• Hazardous Substances Data: 83896-44-0(Hazardous Substances Data)

Usage

Description

18α-Glycylrrhizin, a derivative of Glycyrrhizic Acid, is a triterpene saponin with a wide range of applications in various industries due to its anti-inflammatory, antiulcerous, and antiallergic properties. It is commonly used in traditional Chinese medicinal preparations and has gained significant attention for its potential therapeutic benefits.

Uses

Used in Pharmaceutical Industry:
18α-Glycylrrhizin is used as an active pharmaceutical ingredient for its anti-inflammatory, antiulcerous, and antiallergic effects. It is particularly effective in treating conditions such as gastritis, peptic ulcers, and allergic reactions, providing relief and promoting healing.
Used in Traditional Chinese Medicine:
In traditional Chinese medicine, 18α-Glycylrrhizin is used as a key component in various medicinal formulations. Its anti-inflammatory and antiallergic properties make it a valuable addition to treatments for a range of ailments, including respiratory issues, skin conditions, and gastrointestinal disorders.
Used in Cosmetics Industry:
18α-Glycylrrhizin is used as an ingredient in cosmetic products for its anti-inflammatory and soothing properties. It is particularly beneficial in skincare products, where it can help reduce redness, irritation, and inflammation, promoting a healthy and balanced complexion.
Used in Food and Beverage Industry:
18α-Glycylrrhizin is used as a natural sweetener and flavor enhancer in the food and beverage industry. Its unique taste profile and ability to enhance the flavor of other ingredients make it a popular choice for a variety of products, including beverages, confectionery, and savory dishes.
Used in Nutraceutical Industry:
In the nutraceutical industry, 18α-Glycylrrhizin is used as a dietary supplement for its potential health benefits. It is often included in formulations aimed at promoting gastrointestinal health, reducing inflammation, and supporting the immune system.
Overall, 18α-Glycylrrhizin is a versatile compound with a wide range of applications across various industries, thanks to its unique properties and potential therapeutic benefits. Its use in traditional Chinese medicine, pharmaceuticals, cosmetics, food and beverages, and nutraceuticals highlights its importance and value in modern society.

InChI:InChI=1/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21+,22+,23+,24+,25+,26+,27-,28+,29+,30-,31-,34+,35+,38-,39+,40+,41-,42-/m1/s1

Upstream product

• 118325-23-8 C₆₈H₉₄O₃₀ 
• 118342-92-0 C₅₄H₇₆O₂₁ 
• 118325-22-7 licorice-saponin A₃ 
• 42294-03-1 β-Glycyrrhicic acid tripotassium salt 
• 42294-03-1 β-Glycyrrhicic acid monopotassium salt 
• 68340-31-8 2-O-(β-D-glucopyranosyl)-β-D-glucopyranosyl-11-oxoolean-12-en-30-oate 

Downstream Products

• 184365-69-3 glycyrrhizic acid tris(pentafluorophenyl) ester 
• 927190-20-3 3-O-{2-O-[N-(β-D-glucopyranosyluronoyl)-N^ε-(Z)-L-lysine-t-butyl ester]-N-(β-D-glucopyranosyluronoyl)-N^ε-(Z)-L-lysine-t-butyl ester}-(3β,20β)-11-oxo-olean-12-en-30-carboxylic acid 
• 948913-71-1 C₈₁H₁₀₇N₃O₂₅ 
• 171259-65-7 1-O-<(3β,20β)-11,30-dioxo-30-(N-L-aspartic acid dimethyl ester)-olean-12-en-3-yl>-2-O-<β-D-6-oxo-6-desoxy-6-(N-L-aspartia acid dimethyl ester)-glycopyranosyl>-α-D-6-oxo-6-desoxy-6-(N-L-aspartic acid dimethyl ester)-glucopyranoside 
• 158109-41-2 1-O-<(3β,20β)-11,30-dioxo-30-desoxy-30-(N-L-glutamic acid dimethyl ester)-olean-12-en-3-yl>-2-O-<β-D-6-oxo-6-desoxy-6-(N-L-glutamic acid dimethyl ester)-glycopyranosyl>-α-D-6-oxo-6-desoxy-6-(N-L-glutamic acid dimethyl ester)-glucopyranoside 
• 1416780-06-7 C₆₁H₈₅NO₁₉ 
• 1416780-00-1 C₅₁H₇₃NO₁₇ 
• 1416779-99-1 C₅₁H₇₃NO₁₆ 
• 1416780-05-6 C₆₀H₈₉NO₁₉ 
• 1416779-91-3 C₄₉H₇₁NO₁₄ 
• 1416779-90-2 C₄₈H₇₅NO₁₄ 
• 1416779-84-4 C₅₆H₇₈N₂O₁₃ 
• 1416780-15-8 C₆₃H₈₇NO₂₂ 
• 1416780-14-7 C₆₃H₈₇NO₂₁ 

Relevant articles and documents

METHOD FOR PRODUCING GLYCYRRHIZINIC ACID AND GALACTURO GLYCYRRHIZINIC ACID, AND INTERMEDIATE USED FOR THE PRODUCTION METHOD

PROBLEM TO BE SOLVED: To provide a synthesis method that makes it possible to produce high-purity glycyrrhizinic acid or galacturo glycyrrhizinic acid, simply and in high yields. SOLUTION: A production method includes performing glycosylation of position-3 hydroxy group of glycyrrhetinic acid, then performing selective galactosylation or glycosylation at position-2', and through deprotection, performing selective oxidation of a primary hydroxy group. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Licorice-saponins A3, B2, C2, D3, and E2, five new oleanene-type triterpene oligoglycosides from Chinese glycyrrhizae radix

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