83952-40-3 Usage
Description
(±)5-HEPE, also known as 5-Hydroperoxyeicosapentaenoic acid, is a bioactive lipid mediator produced by the non-enzymatic oxidation of Eicosapentaenoic acid (EPA). It consists of equal amounts of 5(S)-HEPE and 5(R)-HEPE isomers, with the biological activity primarily attributed to the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, as well as human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, including 5-HEPE, 5-oxoEPE, and LTB5, exhibit significantly reduced biological effects compared to the arachidonic acid-derived metabolites.
Uses
Used in Pharmaceutical Industry:
(±)5-HEPE is utilized as a pharmaceutical agent for its anti-inflammatory and immunomodulatory properties. It is known to modulate the production of inflammatory mediators and cytokines, thereby reducing inflammation and promoting tissue repair.
Used in Nutraceutical Industry:
In the nutraceutical industry, (±)5-HEPE is employed as a dietary supplement to support cardiovascular health. Its consumption is believed to help maintain a healthy balance of eicosanoids, which are hormone-like substances derived from fatty acids that play a crucial role in various physiological processes, including blood clotting, immune response, and inflammation.
Used in Research Applications:
(±)5-HEPE is also used in research settings as a tool to study the metabolism and biological effects of EPA and its metabolites. This helps scientists better understand the role of omega-3 fatty acids in human health and disease, as well as develop new therapeutic strategies targeting the eicosanoid pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 83952-40-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,9,5 and 2 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83952-40:
(7*8)+(6*3)+(5*9)+(4*5)+(3*2)+(2*4)+(1*0)=153
153 % 10 = 3
So 83952-40-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h3-4,6-7,9-10,12-14,16,19,21H,2,5,8,11,15,17-18H2,1H3,(H,22,23)/b4-3-,7-6-,10-9-,13-12-,16-14+
83952-40-3Relevant articles and documents
Synthesis of polyconjugated fatty acids
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Page 3; 12, (2010/02/10)
The present invention relates to fatty acids. In particular, the present invention provides polyconjugated fatty acids, and methods of their synthesis and their use.
