84-68-4 Usage
Description
2,2'-dichlorobenzidine, also known as 4,4''-Diamino-2,2''-dichlorobiphenyl, is an organic compound that serves as a valuable reactant in the synthesis of various chemical compounds. It is characterized by the presence of two chlorine atoms attached to a biphenyl structure, which contributes to its reactivity and potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
2,2'-dichlorobenzidine is used as a reactant for the synthesis of benzidine, L-proline, and diaminofluorene derivatives, which are hepatitis C virus NS5A inhibitors. These inhibitors play a crucial role in the development of antiviral drugs to combat hepatitis C, a viral infection that affects the liver and can lead to severe health complications.
In the synthesis process, 2,2'-dichlorobenzidine serves as a key intermediate, providing the necessary structural elements for the formation of the final product. Its reactivity and functional groups make it an ideal candidate for the production of these important pharmaceutical compounds.
Furthermore, the use of 2,2'-dichlorobenzidine in the pharmaceutical industry highlights its potential in contributing to the development of new and effective treatments for various diseases. Its versatility as a reactant allows for the exploration of different chemical pathways and the creation of novel compounds with potential therapeutic applications.
Purification Methods
Crystallise the benzidine from EtOH or H2O. [Beilstein 13 H 234, 13 I 66, 13 II 106, 13 III 477, 13 IV 384.]
Check Digit Verification of cas no
The CAS Registry Mumber 84-68-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 84-68:
(4*8)+(3*4)+(2*6)+(1*8)=64
64 % 10 = 4
So 84-68-4 is a valid CAS Registry Number.
84-68-4Relevant articles and documents
Bidirectional synthesis of the central amino acid of chloptosin
Hong, Wen-Xu,Chen, Ling-Jun,Zhong, Chun-Long,Yao, Zhu-Jun
, p. 4919 - 4922 (2007/10/03)
(Chemical Equation Presented) An efficient total synthesis of (2S,2′S,3aR,3′aR,8aR,8′aR)-6,6′-dichloro-3a, 3′a-dihydroxy-1,1′,2,2′,3,3a,3′,3′a,8,8a,8′, 8′a-dodecahydro-5,5′-bipyr-rolo[2,3-b]indole-2,2′- dicarboxylic acid, the central amino acid component of chloptosin (1), is described. Starting from m-chloronitrobenzene, this C2-symmetrical amino acid was synthesized by using a 14-step route, in which a Zinin benzidine rearrangement, intramolecular Heck reaction, and selenocyclization and oxidative deselenation served as key steps. The absolute stereochemistry of the target was confirmed by X-ray single-crystal studies on a key intermediate (17).
