84048-28-2

Basic information

• Product Name: 7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
• Synonyms: 9-DEOXYFORSKOLIN;7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE;9-deoxyforskolin from coleus forskohlii;9-Deoxyorskolin;7β-Acetoxy-1α,6β-dihydroxy-8,13-epoxy-labd-14-en-11-one
• CAS NO: 84048-28-2
• Molecular Formula: C22H34O6
• Molecular Weight: 394.5
• Mol File: 84048-28-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 490.4°C at 760 mmHg
• Flash Point: 160.7°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 1.13E-11mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: −20°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE(84048-28-2)
• EPA Substance Registry System: 7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE(84048-28-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36/37/38-40
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 84048-28-2(Hazardous Substances Data)

Usage

Description

7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE is a complex organic compound with a unique molecular structure. It is characterized by the presence of a 7-beta-acetoxy group, a 1-alpha position, 6-beta hydroxyl groups, an 8,13-epoxy ring, and a labdane-14-en-11-one backbone. 7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE has potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE is used as a pharmaceutical compound for its potential therapeutic effects. It has been found to activate adenylyl cyclase isoforms, which play a crucial role in various cellular processes, including signal transduction and regulation of intracellular cAMP levels. This activation can lead to a range of physiological effects, making it a promising candidate for the development of new drugs.
Used in Antihypertensive Applications:
7BETA-ACETOXY-1ALPHA,6BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE is also used as an antihypertensive agent. It has the potential to lower blood pressure by modulating the activity of certain enzymes and receptors involved in blood pressure regulation. This can help in the management and treatment of hypertension, a common cardiovascular condition.

InChI:InChI=1/C22H34O6/c1-8-20(5)11-13(24)16-21(6)14(25)9-10-19(3,4)17(21)15(26)18(27-12(2)23)22(16,7)28-20/h8,14-18,25-26H,1,9-11H2,2-7H3/t14-,15-,16+,17-,18-,20-,21+,22-/m0/s1

Downstream Products

• 1055308-36-5 forskolin 

Relevant articles and documents

Method for treating allergic reactions with forskolin

Forskolin and its disclosed derivatives are useful as antiallergic agents. Certain of the derivatives are novel.