840506-40-3

Basic information

• Product Name: L-Alanine, N-[chloro(4-chlorophenoxy)phosphinyl]-, phenylmethyl ester
• CAS NO: 840506-40-3
• Molecular Formula: C16H16Cl2NO4P
• Molecular Weight: 388.187
• Mol File: 840506-40-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[chloro(4-chlorophenoxy)phosphinyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[chloro(4-chlorophenoxy)phosphinyl]-, phenylmethyl ester(840506-40-3)
• EPA Substance Registry System: L-Alanine, N-[chloro(4-chlorophenoxy)phosphinyl]-, phenylmethyl ester(840506-40-3)

Safety Data

• Hazardous Substances Data: 840506-40-3(Hazardous Substances Data)

Upstream product

• 22585-81-5 4-chlorophenylphosphonoyl dichloride 
• 5557-81-3 L-alanine benzyl ester hydrochloride 
• 106-48-9 4-chloro-phenol 
• 772-79-2 4-chlorophenylphosphorodichloridate 

Downstream Products

• 1255860-43-5 C₂₇H₂₉ClN₃O₁₀P 
• 1186412-30-5 C₂₅H₂₇ClN₇O₉P 

Relevant articles and documents

THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION

Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired resistance to gemcitabine. Specifically, provided is a thionucleoside derivative represented by General Formula [1] (in the formula, R1 represents a hydroxyl group which may be protected, a C1-20 alkoxy group which may be substituted, or the like; R2 represents a C1-20 alkoxy group which may be substituted, a C3-8 cycloalkoxy group which may be substituted, or the like; and R3 represents a hydrogen atom or the like); or a salt thereof. Further, provided is a pharmaceutical composition containing such a thionucleoside derivative or a salt thereof.

PHOSPHORAMIDATE PRODRUGS FOR TREATMENT OF VIRAL INFECTION

The invention concerns 2'-methyl ribonucleotide phosphoramidates which are neutral prodrugs which are converted in vivo to 2'- methyl ribonucleotide triphosphates. These compounds are useful in the treatment of viral infection. Of particular interest are prodrugs of a methylsulfonylhydrazinyl purine 2'-methyl nucleotide triphosphate: 2'methyl- N6-alkyl-N6- (N-methylsulfonamide) adenosine triphosphate and its 2-amino derivative.

CHEMICAL COMPOUNDS

Phosphoramidate derivatives of nucleotides and their use in the treatment of cancer are described. The base moieties of, for example, each of deoxyuridine, cytarabine, gemcitabine and citidine may be substituted at the 5-position. The phosphoramidate moiety has attached to the P atom an aryl-O moiety and an α-amino acid moiety. The α-amino acid moiety may correspond to or be derived from either a naturally occurring or a non-naturally occurring amino acid.