84088-50-6

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester
• Synonyms: 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester;1,2-Dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid methyl ester;4-Hydroxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid methyl ester
• CAS NO: 84088-50-6
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.22004
• Mol File: 84088-50-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester(84088-50-6)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester(84088-50-6)

Safety Data

• Hazardous Substances Data: 84088-50-6(Hazardous Substances Data)

Usage

General Description

3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester is a chemical compound with the molecular formula C12H11NO4. It is a methyl ester derivative of 1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid, and it is used in the pharmaceutical industry for its potential medicinal properties. 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester has been studied for its anti-inflammatory and antioxidant effects, as well as its potential in treating neurological disorders and cancer. It is an important chemical in drug discovery and development, and its derivatives may have promising future applications in the field of medicine.

Upstream product

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• 118-48-9 isatoic anhydride 

Downstream Products

• 84088-51-7 1,2-dihydro-4-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester 
• 84088-74-4 N-(4-aminophenyl)-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide 
• 151449-78-4 4-Hydroxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (2-amino-phenyl)-amide 
• 84088-42-6 roquinimex 
• 84088-99-3 N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide 

Relevant articles and documents

Quinolinone compound and application thereof in drugs

The invention relates to a quinolinone compound and application thereof in drugs, particularly relates to a novel quinolinone compound, a pharmaceutical composition thereof and use of the compound or the pharmaceutical composition in preparing drugs. The drug is used for protecting, disposing, treating or alleviating HIF-related and/or EPO-related diseases of patients, wherein the HIF-related and/or EPO-related diseases comprise anemia, vascular diseases, regional myocardial ischaemia, metabolic disturbance, wound healing and the like.

HIGHLY PURE LAQUINIMOD OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Provided herein is an impurity of laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-1- methyl-2-oxoquinoline-3-carboxamide (deschloro laquinimod impurity), and process for preparation and isolation thereof. Provided further herein is a highly pure laquinimod or a pharmaceutically acceptable salt thereof substantially free of deschloro laquinimod impurity, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure laquinimod or a pharmaceutically acceptable salt thereof substantially free of deschloro laquinimod impurity.

A practical method for preparation of 4-hydroxyquinolinone esters

(Chemical Equation Presented) 4-Hydroxyquinolinone esters are a common motif for many medicinal agents. Several methods exist for preparation of these compounds, generally involving the use of sodium hydride, which raises significant safety issues and limits their application to large-scale synthesis. In this note a practical, safe, and general method that employs a combination of diisopropylethylamine and sodium tert-butoxide is described. This allows for the synthesis of 4-hydroxyquinolinone esters and amides in good yields.