84088-88-0

Basic information

• Product Name: Propanoic acid, 3-(methylphenylamino)-3-oxo-, methyl ester
• CAS NO: 84088-88-0
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.229
• Mol File: 84088-88-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 3-(methylphenylamino)-3-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-(methylphenylamino)-3-oxo-, methyl ester(84088-88-0)
• EPA Substance Registry System: Propanoic acid, 3-(methylphenylamino)-3-oxo-, methyl ester(84088-88-0)

Safety Data

• Hazardous Substances Data: 84088-88-0(Hazardous Substances Data)

Upstream product

• 100-61-8 N-methylaniline 
• 15249-31-7 N-phenyl-N-methyl-2-propynamide 
• 67-56-1 methanol 
• 1343395-39-0 3-iodo-N-methyl-N-phenylpropiolamide 
• 16695-14-0 Malonic acid monomethyl ester 
• 37517-81-0 3-chloro-3-oxopropanoic acid methyl ester 

Downstream Products

• 142612-63-3 methyl 2-oxo-1-phenylazetidine-3-carboxylate 
• 1410940-10-1 (±)-methyl 3-benzyl-1-methyl-2-oxoindoline-3-carboxylate 
• 79419-76-4 3-benzyl-3-hydroxy-1-methyl-1,3-dihydroindol-2-one 
• 1618656-92-0 (±)-3-(4-methoxybenzyl)-1,3-dimethylindolin-2-one 
• 1537188-11-6 2-acetyl-3-hydroxy-N-methyl-N-phenylbut-2-enamide 

Relevant articles and documents

Photoinduced Copper-Catalyzed Asymmetric Decarboxylative Alkynylation with Terminal Alkynes

We describe a photoinduced copper-catalyzed asymmetric radical decarboxylative alkynylation of bench-stable N-hydroxyphthalimide(NHP)-type esters of racemic alkyl carboxylic acids with terminal alkynes, which provides a flexible platform for the construction of chiral C(sp3)?C(sp) bonds. Critical to the success of this process are not only the use of the copper catalyst as a dual photo- and cross-coupling catalyst but also tuning of the NHP-type esters to inhibit the facile homodimerization of the alkyl radical and terminal alkyne, respectively. Owing to the use of stable and easily available NHP-type esters, the reaction features a broader substrate scope compared with reactions using the alkyl halide counterparts, covering (hetero)benzyl-, allyl-, and aminocarbonyl-substituted carboxylic acid derivatives, and (hetero)aryl and alkyl as well as silyl alkynes, thus providing a vital complementary approach to the previously reported method.

Development of catalytic deacylative alkylations (DaA) of 3-acyl-2-oxindoles: total synthesis of meso-chimonanthine and related alkaloids

We present an effective deacylative alkylation strategy for the construction of a variety of 2-oxindoles bearing an all-carbon quaternary center at the pseudobenzylic position. A wide variety of products with quaternary centers could be accessed by employing simple Pd(0) catalysis under mild reaction conditions. Importantly, the same strategy works equally well for the dimeric 2-oxindole system, furnishing products with a vicinal quaternary center in favour of meso-isomer as the major product. Eventual application to the total syntheses of meso-chimonanthine and meso-folicanthine very well demonstrates the synthetic potential of this strategy.

Palladium-catalysed intramolecular carbenoid insertion of α-diazo-α-(methoxycarbonyl)acetanilides for oxindole synthesis

A novel, selective palladium-catalysed carbenoid C(aryl)-H insertion of α-diazo-α-(methoxycarbonyl)acetanilides leading to oxindoles is described.