84097-20-1

Basic information

• Product Name: 2,6-dichloro-4-guanidino-pyrimidine
• Synonyms: 2,6-dichloro-4-guanidino-pyrimidine
• CAS NO: 84097-20-1
• Molecular Formula: C5H5Cl2N5
• Molecular Weight: 206
• Mol File: 84097-20-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-dichloro-4-guanidino-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dichloro-4-guanidino-pyrimidine(84097-20-1)
• EPA Substance Registry System: 2,6-dichloro-4-guanidino-pyrimidine(84097-20-1)

Safety Data

• Hazardous Substances Data: 84097-20-1(Hazardous Substances Data)

Usage

General Description

2,6-dichloro-4-guanidino-pyrimidine is a chemical compound with the molecular formula C4H2Cl2N4. It is a derivative of pyrimidine and contains two chlorine atoms and one guanidino group. 2,6-dichloro-4-guanidino-pyrimidine is a potent inhibitor of dihydroorotate dehydrogenase, an enzyme involved in the de novo pyrimidine biosynthesis pathway. It has been studied for its potential use in treating cancer and autoimmune diseases. Additionally, it has also been investigated as an antiviral and antiprotozoal agent. The compound's ability to selectively target key enzymes makes it a promising candidate for the development of new therapeutic agents. However, further research and clinical trials are needed to fully understand its potential uses and safety profile.

Upstream product

• 3764-01-0 2,4,6-trichloropyrimidine 
• 113-00-8 guanidine nitrate 
• 50-01-1 guanidine hydrochloride 

Relevant articles and documents

Investigations of Pt(II) coordination compounds with substituted guanidinopyrimidines

Some new chelates of platinum(II) with substituted guanidinopyrimidines have been prepared and characterized. On the basis of IR and UV-VIS spectra, the structure of the nearest environment of the central ion of these chelates has been characterized and the most likely structures of the obtained coordination compounds were proposed. In each chelate the square-planar coordination sphere of the Pt(II) ion is formed by the guanidinopyrimidine molecule and the halide ligand. Guanidinopyrimidine is the mono- or bidentate ligand binding through the nitrogen atoms of the guanidine group. Halides play a role of terminal and bridging ligands as well.

COORDINATION COMPOUNDS OF COPPER(II) WITH SUBSTITUTED GUANIDINOPYRIMIDINES

Some complexes of copper(II) with 4,6-dichloro-2-guanidinopyrimidine and 2,6-dichloro-4-guanidinopyrimidine have been prepared and characterized.On the basis of vibrational and electronic spectroscopy, magnetism and elemental analysis the structures of these chelates were identified.Thermal behavior of these complexes has also been studied.Substituted guanidinopyrimidines behave as bidentate ligands and are bonded via the N-atom of pyrimidine ring and N-atom of guanidine group with metal ion.