841-95-2Relevant articles and documents
Quinolizidine compound and the manufacturing method thereof
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Paragraph 0324-0330; 0377-0383, (2021/02/19)
Provided are benzoquinolizidine and indoloquinolizidine derivative compounds prepared by performing Mannich reaction using Azza-Michahael response and DDQ oxidizer from tetrahydroisoquinoline or tryptoline, and to a process for preparing the same. The met
Synthesis of (±)-Tetrabenazine by Visible Light Photoredox Catalysis
Orgren, Lindsey R.,Maverick, Emily E.,Marvin, Christopher C.
, p. 12635 - 12640 (2016/01/09)
(±)-Tetrabenazine was synthesized in six steps from commercially available compounds. The key cyclization substrate was assembled rapidly via Baylis-Hillman and aza-Michael reactions. Annulation of the final ring was achieved through visible light photocatalysis, wherein carbon-carbon bond formation was driven by the oxidation of a tertiary amine. Solvent played a critical role in the photoredox cyclization outcome, whereas methanol led to a mixed ketal, acetonitrile/water (10:1) gave direct cyclization to (±)-tetrabenazine and occurred more rapidly.
Asymmetric synthesis of benzoquinolizidines: A formal synthesis of (-)-emetine
Guiles,Meyers
, p. 6873 - 6878 (2007/10/02)
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