84123-78-4Relevant articles and documents
A one-step synthesis of substituted benzo- and pyridine-fused 1H-imidazoles
Kumar, Sonu,Sarmah, Manash P.,Reddy, Yella,Bhatt, Ashish,Kant, Ravi
, p. 96 - 105 (2021/11/23)
Substituted benzimidazoles and pyrimidazoles are an important group of heterocyclic aromatic organic compounds in the field of medicinal chemistry. A one-step microwave accelerated synthesis of substituted benzo- and pyridine-fused 1H-imidazoles has been described. Mechanistically, the reaction proceeds by reacting substituted 2-fluoronitrobenzene and substituted arylamine through the formation of N-hydroxy intermediate, which at higher temperature cleaves to afford the desired product. This approach achieved reductions in reaction times, higher yields, cleaner reactions than the previously described synthetic processes.
Synthesis of benzoxazoles, benzothiazoles and benzimidazoles and evaluation of their antifungal, insecticidal and herbicidal activities
Hisano,Ichikawa,Tsumoto,Tasaki
, p. 2996 - 3004 (2007/10/02)
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