842136-42-9

Basic information

• Product Name: Pyridine, 3-[5-[(5-bromo-2-methylphenyl)methyl]-2-thienyl]-
• CAS NO: 842136-42-9
• Molecular Formula: C17H14BrNS
• Molecular Weight: 344.275
• Mol File: 842136-42-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-[5-[(5-bromo-2-methylphenyl)methyl]-2-thienyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-[5-[(5-bromo-2-methylphenyl)methyl]-2-thienyl]-(842136-42-9)
• EPA Substance Registry System: Pyridine, 3-[5-[(5-bromo-2-methylphenyl)methyl]-2-thienyl]-(842136-42-9)

Safety Data

• Hazardous Substances Data: 842136-42-9(Hazardous Substances Data)

Upstream product

• 1450738-08-5 (5-bromo-2-methylphenyl)(5-(pyridin-3-yl)thiophen-2-yl)methanol 
• 21298-53-3 3-thiophen-2-yl-pyridine 
• 90050-59-2 5-bromo-2-methylbenzaldehyde 

Downstream Products

• 842134-14-9 1-(β-D-glucopyranosyl)-4-methyl-3-[(5-(3-pyridyl)-2-thienyl)methyl]benzene 
• 1450738-09-6 1-(1-methoxy-D-glucopyranosyl)-4-methyl-3-[(5-(3-pyridyl)-2-thienyl)methyl]benzene 

Relevant articles and documents

C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors

Canagliflozin (1), a novel inhibitor for sodium-dependent glucose cotransporter 2 (SGLT2), has been developed for the treatment of type 2 diabetes. To investigate the effect of replacement of the phenyl ring in 1 with heteroaromatics, C-glucosides 2 were designed, synthesized, and evaluated for their inhibitory activities against SGLT2. Of these, 3-pyridyl, 2-pyrimidyl or 5-membered heteroaryl substituted derivatives showed highly potent inhibitory activity against SGLT2, while 5-pyrimidyl substitution was associated with slightly reduced activity. In particular, 2g (TA-3404) had remarkable anti-hyperglycemic effects in high-fat diet fed KK (HF-KK) mice.