842136-44-1

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 4-[(4-chlorophenyl)methoxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-
• CAS NO: 842136-44-1
• Molecular Formula: C18H24ClNO5
• Molecular Weight: 369.845
• Mol File: 842136-44-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[(4-chlorophenyl)methoxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[(4-chlorophenyl)methoxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(842136-44-1)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 4-[(4-chlorophenyl)methoxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-(842136-44-1)

Safety Data

• Hazardous Substances Data: 842136-44-1(Hazardous Substances Data)

Upstream product

• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 622-95-7 4-chlorobenzyl bromide 
• 959130-62-2 (2S,4R)-4-(4-Chloro-benzyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 67-56-1 methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1000991-78-5 C₁₃H₁₆ClNO₃ 
• 842136-07-6 (2S,4R)-4-(4-Chloro-benzyloxy)-2-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 842136-09-8 (2S,4R)-2-azidomethyl-4-(4-chlorobenzyloxy)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 842136-11-2 (2S,4R)-2-Aminomethyl-4-(4-chloro-benzyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 842136-06-5 (2S,4R)-4-(4-chlorobenzyloxy)-2-hydroxymethylpyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design

Structure-based design was utilized to guide the early stage optimization of a substrate-like inhibitor to afford potent peptidomimetic inhibitors of the channel-activating protease prostasin. The first X-ray crystal structures of prostasin with small molecule inhibitors bound to the active site are also reported.

Compounds and Compositions as Channel Activating Protease Inhibitors

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.