84228-43-3

Basic information

• Product Name: Benzoic acid, 3-amino-4-nitro-, ethyl ester
• CAS NO: 84228-43-3
• Molecular Formula: C9H10N2O4
• Molecular Weight: 210.189
• Mol File: 84228-43-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-amino-4-nitro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-amino-4-nitro-, ethyl ester(84228-43-3)
• EPA Substance Registry System: Benzoic acid, 3-amino-4-nitro-, ethyl ester(84228-43-3)

Safety Data

• Hazardous Substances Data: 84228-43-3(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 6968-22-5 3-amino-4-nitrobenzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 54002-27-6 3-acetylamino-4-nitro-benzoic acid 
• 587-48-4 3-acetylaminobenzoic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 89457-09-0 ethyl 2-(trifluoromethyl)-1H-benzo[d]imidazole-5-carboxylate 
• 193014-23-2 ethyl 3-((methyloxyacetyl)amino)-4-nitrobenzoate 
• 193013-89-7 3-acetylamino-4-nitro-benzoic acid ethyl ester 
• 37466-90-3 ethyl 3,4-diaminobenzoate 
• 131508-15-1 3-amino-4-nitro-benzoic acid amide 

Relevant articles and documents

Synthesis of 3,4-diaminobenzoyl derivatives as factor Xa inhibitors

Abstract The coagulation factor Xa (FXa) plays a central role in the blood coagulation cascade. Recent studies have shown that FXa is a particularly attractive target for the development of oral antithrombotic agents. In view of the excellent pharmaceutical properties of 1,2-phenylenediamine-based FXa inhibitors and the reported structureeactivity relationship (SAR) analysis of FXa inhibitors, we designed and synthesized a series of 3,4-diaminobenzoyl-based FXa inhibitors. Intensive SAR studies on this new series led to the discovery of 3,4-dimethoxyl substituted compound 7b. 7b is a highly potent, selective, direct FXa inhibitor with excellent in vivo antithrombotic activity.