843-93-6

Basic information

• Product Name: CP-10447
• Synonyms: CP-10447;3-(4-BroMo-2-Methylphenyl)-2-Methyl-4(3H)-quinazolinone;3-(4-BroMo-o-tolyl)-2-Methyl-4(3H)-quinazolinone
• CAS NO: 843-93-6
• Molecular Formula: C16H13BrN2O
• Molecular Weight: 329.19122
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals
• Mol File: 843-93-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: CP-10447(CAS DataBase Reference)
• NIST Chemistry Reference: CP-10447(843-93-6)
• EPA Substance Registry System: CP-10447(843-93-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 843-93-6(Hazardous Substances Data)

Usage

Description

CP-10447 is a pharmaceutical compound that functions as an inhibitor of apolipoprotein B (apoB) and triglyceride secretion in human hepatoma cells (HepG2). It achieves this by inhibiting the activity of microsomal triglyceride transfer protein (MTP) and stimulating the early endoplasmic reticulum (ER) degradation of apoB. This makes CP-10447 a valuable tool for further research into the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly.

Uses

Used in Pharmaceutical Research:
CP-10447 is used as a research tool for studying the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly. Its ability to inhibit MTP activity and promote the early ER degradation of apoB makes it a valuable asset in understanding the underlying processes and potentially developing treatments for related conditions.
Used in the Development of Treatments for Lipid Disorders:
Due to its inhibitory effects on apoB and triglyceride secretion, CP-10447 may have potential applications in the development of treatments for lipid disorders, such as hyperlipidemia and atherosclerosis. By targeting the key players in lipid metabolism, it could help in managing and treating these conditions more effectively.
Used in the Study of Hepatic Functions:
CP-10447's impact on human hepatoma cells (HepG2) makes it a useful tool for studying hepatic functions and the role of the liver in lipid metabolism. This can contribute to a better understanding of liver-related diseases and the development of targeted therapies.