84315-24-2Relevant articles and documents
Synthetic method of 7-fluoro-5-hydroxy-2,3-dihydro-1hydrogen-indene-1-one
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, (2019/10/10)
The invention relates to a synthetic method of 7-fluoro-5-hydroxy-2,3-dihydro-1hydrogen-indene-1-one. The technical problem that there is no synthetic method suitable for industrialization at present is mainly solved. The synthetic method of the invention
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors
Iserloh,Wu,Cumming,Pan,Wang,Stamford,Kennedy,Kuvelkar,Chen,Parker,Strickland,Voigt
, p. 414 - 417 (2008/04/03)
Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the m
Novel gamma-lactams as beta-secretase inhibitors
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Page/Page column 27, (2010/10/20)
There is provided a series of novel substituted gamma-lactams of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, R5 and R6 as defined herein, their ph