84341-89-9Relevant articles and documents
Application of a domino intramolecular enyne metathesis/cross metathesis reaction to the total synthesis of (+)-8-epi-xanthatin
Kummer, David A.,Brenneman, Jehrod B.,Martin, Stephen F.
, p. 4621 - 4623 (2005)
(Chemical Equation Presented) The first total synthesis of the novel sesquiterpene lactone (+)-8-epi-xanthatin (1) has been achieved starting from the commercially available ester 8. The synthesis features an asymmetric aldol reaction and palladium-catalyzed carbonylation/lactonization sequence leading to 4 and a domino ring-closing enyne metathesis/cross metathesis reaction to afford 1.
Structural variants of mycolactones for use in modulating inflammation, immunity and pain
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Paragraph 0105-0109, (2013/06/05)
The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. ???????? Y-O-W?????(I) wherein Y and W are as defined in claim 1.
Asymmetric total synthesis of the immunosuppressant (-)-pironetin
Bressy, Cyril,Vors, Jean-Pierre,Hillebrand, Stefan,Arseniyadis, Stellios,Cossy, Janine
scheme or table, p. 10137 - 10140 (2009/05/30)
(Chemical Equation Presented) A short, enantioselective total synthesis of the title compound 1 is described. The 14-step synthesis features a highly stereoselective Brown-type pentenylation and a onepot hydrosilylation/ring- closing metathesis (RCM)/prot