843654-83-1Relevant articles and documents
Catalytic Enantioselective Synthesis of Tetrahydocarbazoles and Exocyclic Pictet-Spengler-Type Reactions
Hansen, Casper L.,Ohm, Ragnhild G.,Olsen, Lasse B.,Ascic, Erhad,Tanner, David,Nielsen, Thomas E.
supporting information, p. 5990 - 5993 (2016/12/09)
A synthetic strategy for the synthesis of chiral tetrahydrocarbazoles (THCAs) has been developed. The strategy relies on two types of 6-exo-trig cyclization of 3-substituted indole substrates. Enantioselective domino Friedel-Crafts-type reactions leading to THCAs can be catalyzed by chiral phosphoric acid derivatives (with up to >99% ee), and the first examples of exocyclic Pictet-Spengler reactions to form THCAs are reported.