843666-34-2 Usage
Description
Octadecanoic acid, 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxo-, 1,1-dimethylethyl ester is a complex organic compound with a unique structure that features an ester group, a pyrrolidine ring, and an octadecanoic acid chain. This molecule has the potential to form covalent bonds with primary amines, such as those found in lysine residues or on aminosilane-coated surfaces, under neutral or slightly basic conditions.
Uses
Used in Bioconjugation Applications:
Octadecanoic acid, 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxo-, 1,1-dimethylethyl ester is used as a bioconjugation agent for the specific and efficient attachment of biomolecules, such as proteins or other amine-containing compounds, to various surfaces or supports. The NHS ester moiety allows for the formation of stable covalent bonds with primary amines, enabling the creation of functional bioconjugates for a wide range of applications.
Used in Surface Modification:
In the field of material science, Octadecanoic acid, 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxo-, 1,1-dimethylethyl ester can be used for surface modification. Octadecanoic acid, 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxo-,
1,1-dimethylethyl ester can react with aminosilane-coated surfaces to form covalent bonds, allowing for the attachment of various functional groups or biomolecules onto the surface. This can be useful for creating surfaces with specific properties, such as improved biocompatibility, enhanced catalytic activity, or targeted binding capabilities.
Used in Drug Delivery Systems:
Octadecanoic acid, 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxo-, 1,1-dimethylethyl ester may also find applications in drug delivery systems. The ability to form covalent bonds with primary amines can be utilized to attach drug molecules or other therapeutic agents to various carriers, such as nanoparticles or liposomes. This can improve the stability, solubility, and targeted delivery of drugs, potentially enhancing their therapeutic efficacy and reducing side effects.
Used in Chemical Synthesis:
In the field of organic chemistry, Octadecanoic acid, 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxo-, 1,1-dimethylethyl ester can serve as a valuable intermediate or building block in the synthesis of more complex molecules. The presence of the ester group, pyrrolidine ring, and octadecanoic acid chain provides opportunities for further functionalization and modification, making it a versatile component in the development of new chemical entities with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 843666-34-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,3,6,6 and 6 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 843666-34:
(8*8)+(7*4)+(6*3)+(5*6)+(4*6)+(3*6)+(2*3)+(1*4)=192
192 % 10 = 2
So 843666-34-2 is a valid CAS Registry Number.
843666-34-2Relevant articles and documents
Late-stage lipidation of fully elaborated tryptophan-containing peptides for improved pharmacokinetics
Huang, Chunhui,Wille, Cannon B.,He, Huaibing,Reddy, Vijay Bhasker Gangula,Nargund, Ravi P.,Lin, Songnian,Palani, Anandan
, p. 1219 - 1222 (2017)
The late-stage modification of native peptides to alter and/or enhance their properties and functions is attractive but formidably challenging. Peptide lipidation is one of the effective strategies to overcome short half-life and rapid clearance. Herein, we report a late-stage installation of a fatty acid lipid onto fully elaborated peptides, using glucagon as an example, through regio- and chemoselective functionalization of tryptophan with high potency and remarkable in vivo half-life extension.
METHODS OF MAKING INCRETIN ANALOGS
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Page/Page column 63; 64, (2021/02/26)
Intermediate compounds are disclosed for making incretin analogs, or pharmaceutically acceptable salts thereof. In addition, methods are disclosed for making incretin analogs by coupling from two to four of the intermediate compounds herein via hybrid liquid solid phase synthesis or native chemical ligation.
A process for preparing a fatty acid derivative method and its application (by machine translation)
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, (2018/04/01)
The invention discloses a method for preparing a fatty acid derivative method and its application. The first method is the long-chain fatty acid and thionyl chloride reaction, to obtain the acyl chloride; acyl chloride of preparing butanol reaction, then remove chlorine group, and get long-chain fatty acid uncle ding zhi; then and N - hydroxysuccinimide reaction, long-chain fatty acid succinimide and high yield butylacrylate; then with the L - glutamic acid - 1 - tert-butyl reaction, to obtain tert-butyl long-chain fatty acyl - L - Glu - OtBu; with the N - hydroxysuccinimide reaction, to obtain tert-butyl long-chain fatty acyl - L - Glu (OSu)- OtBu; finally [...] butyl long-chain fatty acyl - L - Glu (OSu)- OtBu tert-butyl in removing, and get long-chain fatty acid derivatives. The method routes the operation is simple, quality is controllable, is suitable for industrial production, and low cost, simple purification at the same time, suitable for use in the preparation of high purity insulin analogs. (by machine translation)
