84378-94-9

Basic information

• Product Name: 4-chloro-5-fluoro-1H-indole-2,3-dione
• Synonyms: 4-chloro-5-fluoro-1H-indole-2,3-dione;4-chloro-5-fluoroisatin;4-Chloro-5-fluoroindoline-2,3-dione
• CAS NO: 84378-94-9
• Molecular Formula: C₈H₃ClFNO₂
• Molecular Weight: 199.57
• Mol File: 84378-94-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.613±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.27±0.20(Predicted)
• CAS DataBase Reference: 4-chloro-5-fluoro-1H-indole-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-5-fluoro-1H-indole-2,3-dione(84378-94-9)
• EPA Substance Registry System: 4-chloro-5-fluoro-1H-indole-2,3-dione(84378-94-9)

Safety Data

• Hazardous Substances Data: 84378-94-9(Hazardous Substances Data)

Usage

Description

4-chloro-5-fluoro-1H-indole-2,3-dione is a synthetic intermediate with the molecular formula C8H4ClFNO2. It is a yellow solid that is insoluble in water but soluble in organic solvents. This chemical compound features a 1H-indole core with a chloro and fluoro substituent, as well as a dione functional group, making it a valuable compound in organic synthesis.

Uses

Used in Pharmaceutical Industry:
4-chloro-5-fluoro-1H-indole-2,3-dione is used as a building block for the synthesis of various biologically active compounds. Its versatile reactivity and functional groups make it a valuable component in the development of pharmaceuticals.
Used in Agrochemical Industry:
4-chloro-5-fluoro-1H-indole-2,3-dione is also used as a synthetic intermediate in the preparation of agrochemicals. Its unique chemical structure contributes to the creation of effective compounds for agricultural applications.

Upstream product

• 108288-15-9 N-(3-Chloro-4-fluorophenyl)-2-(hydroxyimino)acetamide 
• 367-21-5 3-chloro-4-fluorophenylamine 

Relevant articles and documents

Synthesis of substituted tryptanthrin via aryl halides and amines as antitumor and anti-MRSA agents

The natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), and its analogues are found to exhibit potent antitumor and anti-MRSA activities. An efficient and convenient method has been developed for the synthesis of tryptanthrin D-ring derivatives through the reaction of substituted tryptanthrins and secondary amines in moderate to good yields. Some of the new compounds exhibited antitumor activities against the human tumor cell lines A549, HCT116 and MDA-MB-231, with mean IC50 values at low micromolar levels. In addition, some of the compounds showed excellent anti-MRSA activities and were more effective than vancomycin, with MIC values of 0.31–1.25 μg/mL for Mu50,RN4220, and Newman strains.

Utilizing Solubility differences to achieve regiocontrol in the synthesis of substituted quinoline-4-carboxylic acids

A practical method for the regiocontrolled synthesis of substituted quinoline-4-carboxylic acids is described. Solubility differences between the product quinoline regioisomers enable their facile separation, thus avoiding any challenging chromatographic purifications and allowing access to highly substituted quinoline compounds in three steps from commercially available anilines.

TRPV4 ANTAGONISTS

The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.